Impact of IFNL4 -∆G genotype on sustained virologic response in hepatitis C genotype 1 patients treated with direct-acting antivirals
| العنوان: | Impact of IFNL4 -∆G genotype on sustained virologic response in hepatitis C genotype 1 patients treated with direct-acting antivirals |
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| المؤلفون: | Lisa I. Backus, Pamela S. Belperio, Mark Holodniy, Troy A. Shahoumian, Mark A. Winters, Thomas R. O'Brien, Ludmila Prokunina-Olsson |
| المصدر: | Diagnostic Microbiology and Infectious Disease. 92:34-36 |
| بيانات النشر: | Elsevier BV, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, Microbiology (medical), medicine.medical_specialty, Genotype, Sustained Virologic Response, DIRECT ACTING ANTIVIRALS, Antiviral Agents, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Hcv genotype 1, Internal medicine, medicine, Humans, Aged, Aged, 80 and over, business.industry, Interleukins, General Medicine, Odds ratio, Hepatitis C, Hepatitis C, Chronic, Middle Aged, medicine.disease, 030104 developmental biology, Infectious Diseases, Virologic response, Female, 030211 gastroenterology & hepatology, business, Direct acting |
| الوصف: | In direct acting antiviral (DAA)-treated HCV genotype 1, the sustained virologic response rate with the ∆G/∆G genotype of IFNL4 rs368234815 (86.8%) was significantly lower than with ∆G/TT (95.9%, P = 0.03) or TT/TT (98.6%, P = 0.01). The SVR odds ratio for ∆G/∆G compared to TT/TT was 0.10 (P = 0.03). IFNL4 genotype might predict DAA-response. |
| تدمد: | 0732-8893 3682-3481 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c89ddc384e86fa8fb14e854a7b531709Test https://doi.org/10.1016/j.diagmicrobio.2018.04.004Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....c89ddc384e86fa8fb14e854a7b531709 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 07328893 36823481 |
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