The pathological diagnosis of diffuse gliomas: Towards a smart synthesis of microscopic and molecular information in a multidisciplinary context
| العنوان: | The pathological diagnosis of diffuse gliomas: Towards a smart synthesis of microscopic and molecular information in a multidisciplinary context |
|---|---|
| المؤلفون: | Judith W. M. Jeuken, Johan M. Kros, Pieter Wesseling |
| المساهمون: | Pathology, CCA - Disease profiling |
| المصدر: | Diagnostic Histopathology, 17, 486-494 Diagnostic Histopathology, 17, pp. 486-494 Diagnostic Histopathology, 17(11), 486-494. Elsevier BV Wesseling, P, Kros, J M & Jeuken, J W M 2011, ' The pathological diagnosis of diffuse gliomas: Towards a smart synthesis of microscopic and molecular information in a multidisciplinary context ', Diagnostic Histopathology, vol. 17, no. 11, pp. 486-494 . https://doi.org/10.1016/j.mpdhp.2011.08.005Test |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Pathology, medicine.medical_specialty, Histology, business.industry, glioblastoma, Astrocytoma, medicine.disease, Malignancy, oligodendroglioma, Translational research Tissue engineering and pathology [ONCOL 3], nervous system diseases, Pathology and Forensic Medicine, molecular diagnostics, Diffuse Glioma, glioma, Glioma, histopathology, medicine, Histopathology, Oligodendroglioma, astrocytoma, business, neoplasms, Pathological, Grading (tumors) |
| الوصف: | Gliomas form a heterogeneous group of tumours of the central nervous system. Most gliomas, the so-called ‘diffuse gliomas', are characterized by diffuse infiltrative growth in the neuropil. Based on histopathological analysis, diffuse gliomas are subdivided in astrocytic, oligodendroglial, and oligoastrocytic tumours and graded as WHO grade II (low grade), WHO grade III (anaplastic), or WHO grade IV (glioblastoma). Accurate distinction between the different diffuse glioma types and malignancy grades has significant prognostic and therapeutic implications. This review describes essential aspects of the microscopic diagnosis of diffuse gliomas. Because of problems with tissue sampling and imprecise criteria for typing and grading, unequivocal histopathological classification of diffuse gliomas can be challenging. The addition of molecular parameters contributes to a more objective pathological diagnosis of diffuse gliomas. A multidisciplinary approach is mandatory for achieving an optimal diagnosis for patients with these tumours. |
| تدمد: | 0272-7749 1756-2317 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e43cd896e1a8a8fb0e794666e601b08Test https://hdl.handle.net/2066/96454Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5e43cd896e1a8a8fb0e794666e601b08 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 02727749 17562317 |
|---|