Early Pregnancy Serum Concentration of Secreted Frizzled-Related Protein 4, Secreted Frizzled-Related Protein 5, and Chemerin in Obese Women Who Develop Gestational Diabetes Mellitus
| العنوان: | Early Pregnancy Serum Concentration of Secreted Frizzled-Related Protein 4, Secreted Frizzled-Related Protein 5, and Chemerin in Obese Women Who Develop Gestational Diabetes Mellitus |
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| المؤلفون: | Rik H. J. Beernink, Joost H. N. Schuitemaker, Marijke M. Faas, Lucilla Poston, Sara L. White |
| المساهمون: | Analytical Biochemistry, Translational Immunology Groningen (TRIGR), Reproductive Origins of Adult Health and Disease (ROAHD) |
| المصدر: | Diabetology, 3(1), 258-265 Diabetology; Volume 3; Issue 1; Pages: 258-265 |
| بيانات النشر: | MDPI AG, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | secreted frizzled-related protein 4 (sFRP4), secreted frizzled-related protein 5 (sFRP5), chemerin, gestational diabetes mellitus, obesity, nutritional and metabolic diseases |
| الوصف: | Background: The aim of this study was to evaluate whether secreted frizzled-related protein 4 (sFRP4), secreted frizzled-related protein 5 (sFRP5), and chemerin serum concentrations in early pregnancy are associated with the development of gestational diabetes mellitus (GDM) in an obese cohort. In previous studies, increased sFRP4 and chemerin, and decreased sFRP5 concentrations were associated with the development of GDM in normal and overweight women. Methods: In this exploratory case control study, sFRP4, sFRP5, and chemerin serum concentrations were determined by ELISA in 50 obese women who developed GDM and 100 uncomplicated control pregnancies. Serum samples were obtained between 15+0–18+6 weeks’ gestational age and based on a priori known associations with the development of GDM, body mass index (BMI) and maternal age were selected for adjustment in multivariate analyses. Results: In this obese cohort (median BMI 35.7 kg/m2, IQR 33.2–40.3 kg/m2), the biochemical markers showed no association with GDM: sFRP5 odds ratio (OR) 0.44 (95% confidence interval (CI) 0.01–23.18, p = 0.687), sFRP4 OR 0.55 (95% CI 0.09–3.52, p = 0.528), and chemerin OR 3.47 (95% CI 0.05–227.72, p = 0.560). Adjustment for BMI and maternal age did not influence the association. None of the markers were significantly correlated with insulin resistance (HOMA2-IR). Conclusion: No association was found between sFRP4, sFRP5, or chemerin concentration and the development of GDM in a cohort of obese pregnant women. The absence of the association may indicate that these proteins play a lesser biological role in the pathophysiology of GDM in obese women. |
| وصف الملف: | application/pdf |
| تدمد: | 2673-4540 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05f820b123e8c43e3378e8bb3ba675feTest https://doi.org/10.3390/diabetology3010016Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....05f820b123e8c43e3378e8bb3ba675fe |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 26734540 |
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