The negative association between plasma ghrelin and IGF-I is modified by obesity, insulin resistance and type 2 diabetes
| العنوان: | The negative association between plasma ghrelin and IGF-I is modified by obesity, insulin resistance and type 2 diabetes |
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| المؤلفون: | Eija Kellokoski, Seppo M. Pöykkö, Heikki Kauma, Olavi Ukkola, Sohvi Hörkkö, Y A Kesäniemi |
| المصدر: | Diabetologia. 48:309-316 |
| بيانات النشر: | Springer Science and Business Media LLC, 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Arteriosclerosis, Peptide Hormones, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Type 2 diabetes, Peptide hormone, Biology, Insulin-like growth factor-binding protein, Cohort Studies, Insulin resistance, Risk Factors, Internal medicine, Internal Medicine, medicine, Humans, Obesity, Insulin-Like Growth Factor I, Finland, Sex Characteristics, Growth factor, digestive, oral, and skin physiology, Reproducibility of Results, Middle Aged, medicine.disease, Ghrelin, Endocrinology, Diabetes Mellitus, Type 2, biology.protein, Regression Analysis, Female, Insulin Resistance, Hormone |
| الوصف: | Ghrelin is a natural growth hormone-releasing peptide thought to be involved in the regulation of energy metabolism. The recent studies concerning the association between ghrelin and insulin-like growth factor-I (IGF-I) concentrations have shown either negative correlation or no correlation at all. The aims of this study were to clarify the association between ghrelin and IGF-I concentrations in a large cohort and to characterize whether obesity, insulin resistance and type 2 diabetes affect this association.We analysed fasting plasma ghrelin and IGF-I concentrations of 1,004 middle-aged subjects of the population-based OPERA study. Insulin resistance was estimated using QUICKI.IGF-I concentrations were negatively associated with ghrelin concentrations in the analysis of all subjects before (beta=-0.32, p0.001) and after adjustments for BMI, insulin levels, sex and age (beta=-0.40, p0.001). The association was particularly strong in males and in the higher BMI tertiles. The degree of association varied in relation to the glycaemic status: no insulin resistance: r(2)=6.5% (p0.001), insulin resistance without type 2 diabetes: r(2)=21.0% (p0.001), type 2 diabetes: r(2)=25.4 (p0.001). IGF-I levels explained larger proportion (r(2)=9.8%) of the variation in ghrelin concentrations compared to fasting insulin concentration (r(2)=3.0%) and BMI (r(2)=1.5%).There is a negative and independent association between ghrelin and IGF-I concentrations in middle-aged subjects. The interaction between IGF-I and ghrelin is modified by obesity, IR and type 2 diabetes. Further studies are warranted to elucidate the role of ghrelin in the development of these states. |
| تدمد: | 1432-0428 0012-186X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8548538858cd929837e9d6510ca4460Test https://doi.org/10.1007/s00125-004-1635-9Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c8548538858cd929837e9d6510ca4460 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14320428 0012186X |
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