Efficacy of single-hormone and dual-hormone artificial pancreas during continuous and interval exercise in adult patients with type 1 diabetes: randomised controlled crossover trial
| العنوان: | Efficacy of single-hormone and dual-hormone artificial pancreas during continuous and interval exercise in adult patients with type 1 diabetes: randomised controlled crossover trial |
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| المؤلفون: | Virginie Messier, Martin Ladouceur, Rémi Rabasa-Lhoret, Jean-Louis Chiasson, Laurent Legault, Corinne Suppère, Ahmad Haidar, Ali Emami, Nadine Taleb |
| المصدر: | Diabetologia. 59:2561-2571 |
| بيانات النشر: | Springer Science and Business Media LLC, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Adult, Blood Glucose, Male, Pancreas, Artificial, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, 030209 endocrinology & metabolism, 030204 cardiovascular system & hematology, Artificial pancreas, Gastroenterology, Glucagon, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Interquartile range, Internal medicine, Internal Medicine, medicine, Humans, Hypoglycemic Agents, Insulin, Exercise, Type 1 diabetes, Cross-Over Studies, Adult patients, business.industry, Middle Aged, medicine.disease, Crossover study, Diabetes Mellitus, Type 1, Endocrinology, Female, business, Algorithms, Hormone |
| الوصف: | The aim of this study was to assess whether the dual-hormone (insulin and glucagon) artificial pancreas reduces hypoglycaemia compared with the single-hormone (insulin alone) artificial pancreas during two types of exercise. An open-label randomised crossover study comparing both systems in 17 adults with type 1 diabetes (age, 37.2 ± 13.6 years; HbA1c, 8.0 ± 1.0% [63.9 ± 10.2 mmol/mol]) during two exercise types on an ergocycle and matched for energy expenditure: continuous (60% $$ \overset{.}{V}{\mathrm{O}}_{2\mathrm{peak}} $$ for 60 min) and interval (2 min alternating periods at 85% and 50% $$ \overset{.}{V}{\mathrm{O}}_{2\mathrm{peak}} $$ for 40 min, with two 10 min periods at 45% $$ \overset{.}{V}{\mathrm{O}}_{2\mathrm{peak}} $$ at the start and end of the session). Blocked randomisation (size of four) with a 1:1:1:1 allocation ratio was computer generated. The artificial pancreas was applied from 15:30 hours until 19:30 hours; exercise was started at 18:00 hours and announced 20 min earlier to the systems. The study was conducted at the Institut de recherches cliniques de Montreal. During single-hormone control compared with dual-hormone control, exercise-induced hypoglycaemia (plasma glucose |
| تدمد: | 1432-0428 0012-186X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cf505cd7fd18d7a46a2b7fc39451b87Test https://doi.org/10.1007/s00125-016-4107-0Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8cf505cd7fd18d7a46a2b7fc39451b87 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14320428 0012186X |
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