التفاصيل البيبلوغرافية
العنوان:
Genome-wide association study in a Chinese population identifies a susceptibility locus for type 2 diabetes at 7q32 near PAX4
المؤلفون:
Weihui Yu , Claudia Ht Tam , Lianying Ji , Patrick Kwan , Renming Hu , Toshimasa Yamauchi , E-Shyong Tai , Yanan Wang , Larry Baum , Ling Lu , Congrong Wang , Jiqiu Wang , Aaron G. Day-Williams , X. Zhang , Hui Mien Lee , Jing-Woei Li , Ho Cheung William Li , Andrew P. Morris , Eleftheria Zeggini , Brian Tomlinson , Xu（林旭） Lin , Cheng Hu , Jianjun Liu , H.Y. Sy , Min Jin Go , Hideo Fujita , Jean Woo , Stacey S. Cherny , Ronald C.W. Ma , Kazuo Hara , Wing-Yee So , X. Ma , Sarah Keildson , Young-Jin Kim , Ping-Chung Leung , Y. J. Fang , Alex C.W. Ng , Sheng Tang , Janice S. K. Ho , Xueling Sim , Stephen Kwok-Wing Tsui , GN Thomas , Kalliope Panoutsopoulou , Maggie C.Y. Ng , Gang Xu , Daniel P.K. Ng , Nelson L.S. Tang , X. Hou , Juliana C.N. Chan , T. F. Chan , Jieli Lu , Rong Zhang , Ting Fan Leung , Feng Jiang , Yoon Shin Cho , Weiping Jia , Tien Yin Wong , Jong-Young Lee , Kam Lun Hon , Yuqian Bao , Alice P.S. Kong , Vincent Kl Lam , Kun-san Xiang , Shiro Maeda , Mark I. McCarthy , Takashi Kadowaki
المصدر:
Diabetologia
سنة النشر:
2013
مصطلحات موضوعية:
Male , JAPANESE , Endocrinology, Diabetes and Metabolism , Genome-wide association study , Type 2 diabetes , VARIANTS , MELLITUS , 0302 clinical medicine , Japan , Insulin-Secreting Cells , Genotype , Paired Box Transcription Factors , Genetics , Singapore , 0303 health sciences , Diabetes , Middle Aged , 3. Good health , Hong Kong , Female , Chromosomes, Human, Pair 7 , Adult , Genetic Markers , EXPRESSION , China , East Asians , 030209 endocrinology & metabolism , Biology , Article , 03 medical and health sciences , Asian People , HUMAN PANCREATIC-ISLETS , Diabetes mellitus , Genetic variation , Internal Medicine , medicine , LINKAGE , Humans , Genetic Predisposition to Disease , Gene , METAANALYSIS , POLYMORPHISMS , Aged , 030304 developmental biology , Genetic association , Homeodomain Proteins , Chinese , MUTATIONS , Genetic Variation , medicine.disease , GENE , Diabetes Mellitus, Type 2 , Genetic marker
الوصف:
Aims/hypothesis Most genetic variants identified for type 2 diabetes have been discovered in European populations. We performed genome-wide association studies (GWAS) in a Chinese population with the aim of identifying novel variants for type 2 diabetes in Asians. Methods We performed a meta-analysis of three GWAS comprising 684 patients with type 2 diabetes and 955 controls of Southern Han Chinese descent. We followed up the top signals in two independent Southern Han Chinese cohorts (totalling 10,383 cases and 6,974 controls), and performed in silico replication in multiple populations. Results We identified CDKN2A/B and four novel type 2 diabetes association signals with p
وصف الملف:
application/pdf
اللغة:
English
تدمد:
1432-0428
الوصول الحر:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9174dfdb8b4cf4676ad1056e692bfd1Test http://ora.ox.ac.uk/objects/uuid:8c4acaf0-9882-42d7-91e9-977196899cd9Test
حقوق:
OPEN
رقم الانضمام:
edsair.doi.dedup.....a9174dfdb8b4cf4676ad1056e692bfd1
قاعدة البيانات:
OpenAIRE
