Skeletal muscle microvascular exchange capacity is associated with hyperglycaemia in subjects with central obesity
| العنوان: | Skeletal muscle microvascular exchange capacity is associated with hyperglycaemia in subjects with central obesity |
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| المؤلفون: | Geraldine F. Clough, Christopher D. Byrne, Magdalena Turzyniecka, Andrew J. Chipperfield, J. Gamble, Sarah H. Wild, Andrew J. Krentz |
| المصدر: | Diabetic Medicine. 26:1112-1119 |
| بيانات النشر: | Wiley, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Blood sugar, Type 2 diabetes, Metabolic equivalent, chemistry.chemical_compound, Endocrinology, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, Humans, Muscle, Skeletal, Glycated Hemoglobin, business.industry, Microcirculation, Insulin, Skeletal muscle, VO2 max, Middle Aged, medicine.disease, Plethysmography, medicine.anatomical_structure, Diabetes Mellitus, Type 2, chemistry, Hyperglycemia, Obesity, Abdominal, Female, Glycated hemoglobin, business |
| الوصف: | Aims: poor glycaemic control is associated with increased risk of microvascular disease in various organs including the eye and kidney, but the relationship between glycated haemoglobin (HbA1c) and microvascular function in skeletal muscle has not been described. We tested the association between HbA1c and a measure of microvascular exchange capacity (Kf) in skeletal muscle in people with central obesity at risk of developing Type 2 diabetes. Methods: microvascular function was measured in 28 women and 19 men [mean (± sd) age 51 ± 9 years] with central obesity who did not have diabetes. We estimated insulin sensitivity by hyperinsulinaemic–euglycaemic clamp, visceral and total fatness by magnetic resonance imaging, fitness (VO2 max by treadmill testing), physical activity energy expenditure [metabolic equivalents of tasks (METS) by use of the SenseWear Pro armband] and skeletal muscle microvascular exchange capacity (Kf) by venous occlusion plethysmography. Results: in regression modelling, age, sex and fasting plasma glucose accounted for 30.5% of the variance in HbA1c (r2 = 0.31, P = 0.001). Adding Kf to this model explained an additional 26.5% of the variance in HbA1c (r2 = 0.57, P = 0.0001 and Kf was strongly and independently associated with HbA1c (standardized B coefficient ?0.45 (95% confidence interval ?0.19, ?0.06), P = 0.001). Conclusions: we found a strong negative independent association between a measure of skeletal muscle microvascular exchange capacity (Kf) and HbA1c. Kf was associated with almost as much of the variance in HbA1c as fasting plasma glucose |
| تدمد: | 1464-5491 0742-3071 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd1f1fe8839db20af971044f13d6c30fTest https://doi.org/10.1111/j.1464-5491.2009.02822.xTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....fd1f1fe8839db20af971044f13d6c30f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14645491 07423071 |
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