Effectiveness of Exenatide in Asian Indians in a Clinical Care Setting
| العنوان: | Effectiveness of Exenatide in Asian Indians in a Clinical Care Setting |
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| المؤلفون: | Ranjit Mohan Anjana, Chidambarann Sudhakaran, Maryam Fathima, Viswanathan Mohan, Ranjit Unnikrishnan I |
| المصدر: | Diabetes Technology & Therapeutics. 12:613-618 |
| بيانات النشر: | Mary Ann Liebert Inc, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Adult, Blood Glucose, Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Insulin, Isophane, India, Insulin Glargine, NPH insulin, Hypoglycemia, chemistry.chemical_compound, Endocrinology, Asian People, Surveys and Questionnaires, Internal medicine, Diabetes mellitus, medicine, Humans, Hypoglycemic Agents, Insulin, Aged, Glycemic, Glycated Hemoglobin, Venoms, Insulin glargine, business.industry, Body Weight, Type 2 Diabetes Mellitus, Middle Aged, medicine.disease, Insulin, Long-Acting, Medical Laboratory Technology, Treatment Outcome, Diabetes Mellitus, Type 2, chemistry, Exenatide, Female, Glycated hemoglobin, Peptides, business, medicine.drug |
| الوصف: | This study reports on the effectiveness of exenatide compared to insulin glargine or NPH insulin in patients with type 2 diabetes mellitus, unable to achieve glycemic control with oral glucose-lowering therapies in a clinical care setting.Patients with type 2 diabetes mellitus (n = 47) whose glycemia was not controlled adequately with oral hypoglycemic agents at maximum recommended therapeutic doses were initiated on exenatide therapy. Age-, sex-, and body mass index-matched patients receiving insulin glargine (n = 54) or NPH insulin (n = 23) served as controls. Data analysis included glycated hemoglobin, fasting and postprandial plasma glucose, lipid profile, body weight, and the occurrence of hypoglycemia.A statistically significant reduction in glycated hemoglobin value was noted after initiating exenatide (pre-exenatide 9.7 +/- 1.4% vs. post-exenatide 8.7 +/- 1.5%; P0.05), which was comparable to values after insulin glargine (9.8 +/- 1.1% vs. 9.0 +/- 1.5%, respectively; P0.05) and NPH insulin (9.6 +/- 1.4% vs. 8.9 +/- 1.3%, respectively; P0.05). Exenatide therapy was associated with net weight loss (mean, 1.6 kg), but therapy with insulin glargine and NPH insulin was associated with weight gain (1.8 and 2.3 kg, respectively).In a group of select Asian Indian type 2 diabetes patients with secondary failure to oral hypoglycemic agents seen at a diabetes center, exenatide treatment in combination with oral drug regimens resulted in significant lowering of glycated hemoglobin similar to insulin glargine or NPH insulin but with the additional benefit of weight loss, albeit a small amount. |
| تدمد: | 1557-8593 1520-9156 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd897108b0108c895874f19cfd3cb65bTest https://doi.org/10.1089/dia.2010.0033Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....cd897108b0108c895874f19cfd3cb65b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15578593 15209156 |
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