Glucose-Independent Ethnic Differences in HbA1c in People Without Known Diabetes
| العنوان: | Glucose-Independent Ethnic Differences in HbA1c in People Without Known Diabetes |
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| المؤلفون: | Noorjehan Joonas, Jaakko Tuomilehto, Sudhir Kowlessur, Jose Larhubarbe, Matthew J.L. Hare, Paul Zimmet, Vassen Pauvaday, Stefan Söderberg, Jonathan E. Shaw, K. George M.M. Alberti, Dianna J. Magliano |
| المصدر: | Diabetes Care |
| بيانات النشر: | American Diabetes Association, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Adult, Blood Glucose, Glycated Hemoglobin, Male, Advanced and Specialized Nursing, Gerontology, Glucose tolerance test, South asia, medicine.diagnostic_test, business.industry, Endocrinology, Diabetes and Metabolism, Ethnic group, Glucose Tolerance Test, Middle Aged, medicine.disease, Diabetes mellitus, Diabetes Mellitus, Internal Medicine, Humans, Medicine, Female, Epidemiology/Health Services Research, business, Aged, Original Research |
| الوصف: | OBJECTIVE To determine whether glucose-independent differences in HbA1c exist between people of African, South Asian, and Chinese ethnicities. RESEARCH DESIGN AND METHODS Data from 6,701 people aged 19–78 years, without known diabetes, from Mauritius, and participating in the population-based Non-Communicable Disease Surveys of the main island and the island of Rodrigues were included. Participants were African (n = 1,219 from main island, n = 1,505 from Rodrigues), South Asian (n = 3,820), and Chinese (n = 157). Survey data included HbA1c, plasma glucose during oral glucose tolerance testing (OGTT), anthropometry, demographics, and medical and lifestyle history. RESULTS Mean HbA1c, after adjustment for fasting and 2-h plasma glucose and other factors known to influence HbA1c, was higher in Africans from Rodrigues (6.1%) than in South Asians (5.7%, P < 0.001), Chinese (5.7%, P < 0.001), or Africans from the main island of Mauritius (5.7%, P < 0.001). The age-standardized prevalence of diabetes among Africans from Rodrigues differed substantially depending on the diagnostic criteria used [OGTT 7.9% (95% CI 5.8–10.0); HbA1c 17.3% (15.3–19.2)]. Changing diagnostic criteria resulted in no significant change in the prevalence of diabetes within the other ethnic groups. CONCLUSIONS People of African ethnicity from Rodrigues have higher HbA1c than those of South Asian or African ethnicity from the main island of Mauritius for reasons not explained by plasma glucose during an OGTT or traditional factors known to affect glycemia. Further research should be directed at determining the mechanism behind this disparity and its relevance to clinical outcomes. |
| تدمد: | 1935-5548 0149-5992 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aab50bbd88f180f139230d163be566aTest https://doi.org/10.2337/dc12-1210Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2aab50bbd88f180f139230d163be566a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19355548 01495992 |
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