التفاصيل البيبلوغرافية
| العنوان: |
Low-Dose Antithymocyte Globulin: A Pragmatic Approach to Treating Stage 2 Type 1 Diabetes. |
| المؤلفون: |
Foster, Timothy P., Jacobsen, Laura M., Bruggeman, Brittany, Salmon, Chelsea, Hosford, Jennifer, Chen, Angela, Cintron, Miriam, Mathews, Clayton E., Wasserfall, Clive, Brusko, Maigan A., Brusko, Todd M., Atkinson, Mark A., Schatz, Desmond A., Haller, Michael J. |
| المصدر: |
Diabetes Care; Feb2024, Vol. 47 Issue 2, p285-289, 5p |
| مصطلحات موضوعية: |
TYPE 1 diabetes, TYPE 2 diabetes, CONTINUOUS glucose monitoring, GLOBULINS |
| مستخلص: |
OBJECTIVE: Low-dose antithymocyte globulin (ATG) (2.5 mg/kg) preserves C-peptide and reduces HbA1c in new-onset stage 3 type 1 diabetes, yet efficacy in delaying progression from stage 2 to stage 3 has not been evaluated. RESEARCH DESIGN AND METHODS: Children (n = 6) aged 5–14 years with stage 2 type 1 diabetes received off-label, low-dose ATG. HbA1c, C-peptide, continuous glucose monitoring, insulin requirements, and side effects were followed for 18–48 months. RESULTS: Three subjects (50%) remained diabetes free after 1.5, 3, and 4 years of follow-up, while three developed stage 3 within 1–2 months after therapy. Eighteen months posttreatment, even disease progressors demonstrated near-normal HbA1c (5.1% [32 mmol/mol], 5.6% [38 mmol/mol], and 5.3% [34 mmol/mol]), time in range (93%, 88%, and 98%), low insulin requirements (0.17, 0.18, and 0.34 units/kg/day), and robust C-peptide 90 min after mixed meal (1.3 ng/dL, 2.3 ng/dL, and 1.4 ng/dL). CONCLUSIONS: These observations support additional prospective studies evaluating ATG in stage 2 type 1 diabetes. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
