التفاصيل البيبلوغرافية
| العنوان: |
Diabetes Is Associated With Worse Long-term Outcomes in Young Adults After Myocardial Infarction: The Partners YOUNG-MI Registry. |
| المؤلفون: |
Divakaran, Sanjay, Singh, Avinainder, Biery, David, Yang, Junjie, DeFilippis, Ersilia M., Collins, Bradley L., Ramsis, Mattheus, Qamar, Arman, Hainer, Jon, Klein, Josh, Cannon, Christopher P., Polk, Donna M., Plutzky, Jorge, Nasir, Khurram, Januzzi, James L., Di Carli, Marcelo F., Bhatt, Deepak L., Blankstein, Ron |
| المصدر: |
Diabetes Care; Aug2020, Vol. 43 Issue 8, p1843-1850, 8p |
| مصطلحات موضوعية: |
MYOCARDIAL infarction complications, DIAGNOSIS of diabetes, MYOCARDIAL infarction diagnosis, MYOCARDIAL infarction-related mortality, AGE distribution, TIME, DIABETES, RETROSPECTIVE studies, PROGNOSIS, ACQUISITION of data, RESEARCH funding, DIABETIC angiopathies, LONGITUDINAL method |
| مصطلحات جغرافية: |
UNITED States |
| مستخلص: |
Objective: We sought to determine the prevalence of diabetes and associated cardiovascular outcomes in a contemporary cohort of young individuals presenting with their first myocardial infarction (MI) at age ≤50 years.Research Design and Methods: We retrospectively analyzed records of patients presenting with a first type 1 MI at age ≤50 years from 2000 to 2016. Diabetes was defined as a hemoglobin A1c ≥6.5% (48 mmol/mol) or a documented diagnosis of or treatment for diabetes. Vital status was ascertained for all patients, and cause of death was adjudicated.Results: Among 2,097 young patients who had a type 1 MI (mean age 44.0 ± 5.1 years, 19.3% female, 73% white), diabetes was present in 416 (20%), of whom 172 (41%) were receiving insulin. Over a median follow-up of 11.2 years (interquartile range 7.3-14.2 years), diabetes was associated with a higher all-cause mortality (hazard ratio 2.30; P < 0.001) and cardiovascular mortality (2.68; P < 0.001). These associations persisted after adjusting for baseline covariates (all-cause mortality: 1.65; P = 0.008; cardiovascular mortality: 2.10; P = 0.004).Conclusions: Diabetes was present in 20% of patients who presented with their first MI at age ≤50 years and was associated with worse long-term all-cause and cardiovascular mortality. These findings highlight the need for implementing more aggressive therapies aimed at preventing future adverse cardiovascular events in this population. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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