Metabolic syndrome, prediabetes, and brain abnormalities onmri in patients with manifest arterial disease
| العنوان: | Metabolic syndrome, prediabetes, and brain abnormalities onmri in patients with manifest arterial disease |
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| المؤلفون: | Tiehuis, A.M., Graaf, Y. van der, Mali, W.P.T.M., Vincken, K., Muller, M., Geerlings, M.I., SMART Study Grp |
| المساهمون: | Internal medicine, ACS - Atherosclerosis & ischemic syndromes |
| المصدر: | Diabetes Care, 37(9), 2515-2521 Tiehuis, A M, Van Der Graaf, Y, Mali, W P T M, Vincken, K, Muller, M & Geerlings, M I 2014, ' Metabolic syndrome, prediabetes, and brain abnormalities onmri in patients with manifest arterial disease : The smart-mr study ', Diabetes Care, vol. 37, no. 9, pp. 2515-2521 . https://doi.org/10.2337/dc14-0154Test Diabetes Care, 37(9), 2515-2521. American Diabetes Association Inc. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Aging, Endocrinology, Diabetes and Metabolism, Coronary Artery Disease, Prediabetic State, Peripheral Arterial Disease, Risk Factors, Diabetes mellitus, Internal medicine, Internal Medicine, Medicine, Humans, Prediabetes, Prospective Studies, Abdominal obesity, Advanced and Specialized Nursing, Metabolic Syndrome, Brain Diseases, business.industry, Hypertriglyceridemia, Middle Aged, medicine.disease, Obesity, Magnetic Resonance Imaging, Hyperintensity, Endocrinology, Cross-Sectional Studies, Brain size, Cardiology, Disease Progression, Female, Cerebral Arterial Diseases, Metabolic syndrome, medicine.symptom, business |
| الوصف: | OBJECTIVE Metabolic syndrome (MetS) is a cluster of cardiovascular risk factors leading to atherosclerosis and diabetes. Diabetes is associated with both structural and functional abnormalities of the brain. MetS, even before diabetes is diagnosed, may also predispose to cerebral changes, probably through shared mechanisms. We examined the association of MetS with cerebral changes in patients with manifest arterial disease. RESEARCH DESIGN AND METHODS Cross-sectional data on MetS and brain MRI were available in 1,232 participants with manifest arterial disease (age 58.6 ± 10.1 years; 37% MetS). Volumes of brain tissue, ventricles, and white matter hyperintensities (WMH) were obtained by automated segmentation and expressed relative to intracranial volume. Infarcts were distinguished into lacunar and nonlacunar infarcts. RESULTS The presence of MetS (n = 451) was associated with smaller brain tissue volume (B −0.72% [95% CI −0.97, −0.47]), even in the subgroup of patients without diabetes (B −0.42% [95% CI −0.71, −0.13]). MetS was not associated with an increased occurrence of WMH or cerebral infarcts. Impaired glucose metabolism, abdominal obesity, and elevated triglycerides were individual components associated with smaller brain volume. Obesity and hypertriglyceridemia remained associated with smaller brain volume when patients with diabetes were excluded. Hypertension was associated with an increased occurrence of WMH and infarcts. CONCLUSIONS In patients with manifest arterial disease, presence of MetS is associated with smaller brain volume, even in patients without diabetes. Screening for MetS and treatment of its individual components, in particular, hyperglycemia, hypertriglyceridemia, and obesity, may prevent progression of cognitive aging in patients with MetS, even in a prediabetic stage. |
| اللغة: | English |
| تدمد: | 0149-5992 2515-2521 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08e52e6d1db3fb6b023794ec50e40e50Test http://www.scopus.com/inward/record.url?scp=84906701270&partnerID=8YFLogxKTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....08e52e6d1db3fb6b023794ec50e40e50 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 01495992 25152521 |
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