Prednisone Treatment in Newly Diagnosed Type I Diabetic Children: 1-Yr Follow-Up
| العنوان: | Prednisone Treatment in Newly Diagnosed Type I Diabetic Children: 1-Yr Follow-Up |
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| المؤلفون: | Luciano Beccaria, Franco Meschi, C Pellini, L Mistura, Giuseppe Chiumello, A Flores D'Arcais, M. Puzzovio |
| المصدر: | Diabetes Care. 10:39-43 |
| بيانات النشر: | American Diabetes Association, 1987. |
| سنة النشر: | 1987 |
| مصطلحات موضوعية: | Male, Glycosuria, medicine.medical_specialty, Adolescent, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Newly diagnosed, Gastroenterology, chemistry.chemical_compound, Prednisone, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, Humans, Insulin, Child, Glycated Hemoglobin, Advanced and Specialized Nursing, Prednisone treatment, C-Peptide, C-peptide, business.industry, Type i diabetes mellitus, Fasting, medicine.disease, Diabetes Mellitus, Type 1, Endocrinology, chemistry, Food, Female, medicine.symptom, business, medicine.drug |
| الوصف: | Thirty-one children suffering from type I diabetes mellitus were arranged at onset of the disease in two different groups. Group 1 was treated with oral prednisone (60 mg · m−2 · day−1 for 14 days, 30 and 15 mg · m−2 · day−1 for 7 days). Group 2 matched the control group. All patients were treated with continuous subcutaneous insulin infusion for the first 15 days of treatment, and then with two daily injections of a mixture of intermediate- and fast-acting insulin. All subjects were followed for 1 yr. Group 1 required more insulin than group 2 after 30 days (1.5 ± 0.3 vs. 0.6 + 0.2 U · kg−1 · day−1, P < .001) and after 60 days (0.8 ± 0.1 vs. 0.5 ± 0.06 U · kg−1 · day−1, P < .001). After 3 mo, both groups reached the lowest mean stable HbA1 level (8.4 ± 0.4 and 8.3 ± 0.4% group 1 and 2 respectively). Between the 2nd and 9th mo of follow-up, mean postbreakfast C-peptide concentration increased in both groups. The highest levels of fasting C-peptide were reached by group 1 after 90 days (0.77 ± 0.32 nM) and group 2 after 60 days (0.34 ± 0.09 nM). The largest partial remission (C-peptide 0.3 nM, insulin requirement |
| تدمد: | 1935-5548 0149-5992 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0436e379443ebf865b0a175310056d3bTest https://doi.org/10.2337/diacare.10.1.39Test |
| رقم الانضمام: | edsair.doi.dedup.....0436e379443ebf865b0a175310056d3b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19355548 01495992 |
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