Hypoglycemia and Risk of Cardiovascular Disease and All-Cause Mortality in Insulin-Treated People With Type 1 and Type 2 Diabetes: A Cohort Study
| العنوان: | Hypoglycemia and Risk of Cardiovascular Disease and All-Cause Mortality in Insulin-Treated People With Type 1 and Type 2 Diabetes: A Cohort Study |
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| المؤلفون: | Azeem Majeed, Kamlesh Khunti, Brian Larsen Thorsted, Melanie J. Davies, Michael L. Wolden, Sanjoy K. Paul |
| المصدر: | Diabetes Care. 38:316-322 |
| بيانات النشر: | American Diabetes Association, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Population, Insulins, Type 2 diabetes, Hypoglycemia, Interquartile range, Internal medicine, Internal Medicine, medicine, Humans, Hypoglycemic Agents, education, Aged, Advanced and Specialized Nursing, Type 1 diabetes, education.field_of_study, business.industry, Hazard ratio, Retrospective cohort study, Middle Aged, medicine.disease, Diabetes Mellitus, Type 1, Endocrinology, Diabetes Mellitus, Type 2, England, Female, Epidemiologic Methods, business, Diabetic Angiopathies, Cohort study |
| الوصف: | OBJECTIVE Hypoglycemia has been associated with an increased risk of cardiovascular (CV) events and all-cause mortality. This study assessed whether, in a nationally representative population, there is an association between hypoglycemia, the risk of CV events, and all-cause mortality among insulin-treated people with type 1 diabetes or type 2 diabetes. RESEARCH DESIGN AND METHODS This retrospective cohort study used data from the Clinical Practice Research Datalink database and included all insulin-treated patients (≥30 years of age) with a diagnosis of diabetes. RESULTS In patients who experienced hypoglycemia, hazard ratios (HRs) for CV events in people with type 1 diabetes were 1.51 (95% CI 0.83, 2.75; P = ns) and 1.61 (1.17, 2.22), respectively, for those with and without a history of CV disease (CVD) before the index date. In people with type 2 diabetes, the HRs for patients with and without a history of CVD were 1.60 (1.21, 2.12) and 1.49 (1.23, 1.82), respectively. For all-cause mortality, HRs in people with type 1 diabetes were 1.98 (1.25, 3.17), and 2.03 (1.66, 2.47), respectively, for those with and without a history of CVD. Among people with type 2 diabetes, HRs were 1.74 (1.39, 2.18) and 2.48 (2.21, 2.79), respectively, for those with and without a history of CVD. The median time (interquartile range) from first hypoglycemia event to first CV event was 1.5 years (0.5, 3.5 years) and 1.5 years (0.5, 3.0 years), respectively, for people with type 1 and type 2 diabetes. CONCLUSIONS Hypoglycemia is associated with an increased risk of CV events and all-cause mortality in insulin-treated patients with diabetes. The relationship between hypoglycemia and CV outcomes and mortality exists over a long period. |
| تدمد: | 1935-5548 0149-5992 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad82cf22d00667f59014ee03c2659a36Test https://doi.org/10.2337/dc14-0920Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ad82cf22d00667f59014ee03c2659a36 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19355548 01495992 |
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