Pioglitazone Decreases Plasma Cholesteryl Ester Transfer Protein Mass, Associated With a Decrease in Hepatic Triglyceride Content, in Patients With Type 2 Diabetes
| العنوان: | Pioglitazone Decreases Plasma Cholesteryl Ester Transfer Protein Mass, Associated With a Decrease in Hepatic Triglyceride Content, in Patients With Type 2 Diabetes |
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| المؤلفون: | Hildo J. Lamb, Jacqueline T. Jonker, Patrick C.N. Rensen, Michaela Diamant, Willeke de Haan, Rutger W. van der Meer, Luuk J. Rijzewijk, Johannes W. A. Smit, Johannes A. Romijn, Jouke T. Tamsma, Albert de Roos, Yanan Wang |
| المساهمون: | General Internal Medicine, Internal medicine, ICaR - Ischemia and repair |
| المصدر: | Diabetes Care Diabetes care, 33(7), 1625-1628. American Diabetes Association Inc. Jonker, J T, Wang, Y N, de Haan, W, Diamant, M, Rijzewijk, L J, van der Meer, R W, Lamb, H J, Tamsma, J T, de Roos, A, Romijn, J A, Rensen, P C N & Smit, J W A 2010, ' Pioglitazone Decreases Plasma Cholesteryl Ester Transfer Protein Mass, Associated With a Decrease in Hepatic Triglyceride Content, in Patients With Type 2 Diabetes ', Diabetes Care, vol. 33, no. 7, pp. 1625-1628 . https://doi.org/10.2337/dc09-1935Test Diabetes Care, 33(7), 1625-1628. American Diabetes Association Inc. Diabetes Care, 33(7), 1625-1628 |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Cardiovascular and Metabolic Risk, Endocrinology, Diabetes and Metabolism, Type 2 diabetes, Placebos, chemistry.chemical_compound, Internal medicine, Cholesterylester transfer protein, Internal Medicine, medicine, Humans, Hypoglycemic Agents, Prospective Studies, Triglycerides, Original Research, Advanced and Specialized Nursing, increases hdl-cholesterol cetp expression rosiglitazone dyslipidemia accumulation steatosis metformin mellitus liver mice, Triglyceride, biology, Pioglitazone, Cholesterol, business.industry, Middle Aged, medicine.disease, Magnetic Resonance Imaging, Metformin, Cholesterol Ester Transfer Proteins, Glimepiride, Endocrinology, Sulfonylurea Compounds, chemistry, Diabetes Mellitus, Type 2, Liver, Apolipoprotein B-100, biology.protein, lipids (amino acids, peptides, and proteins), Drug Therapy, Combination, Thiazolidinediones, Steatosis, Hydroxymethylglutaryl-CoA Reductase Inhibitors, business, medicine.drug |
| الوصف: | OBJECTIVE Thiazolidinediones reduce hepatic steatosis and increase HDL cholesterol levels. In mice with human-like lipoprotein metabolism (APOE*3-Leiden.CETP transgenic mice), a decrease in hepatic triglyceride content is associated with a decrease in plasma cholesteryl ester transfer protein (CETP) mass and an increase in HDL levels. Therefore, the aim of the present study was to assess the effects of pioglitazone on CETP mass in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS We included 78 men with type 2 diabetes (aged 56.5 ± 0.6 years; HbA1c 7.1 ± 0.1%) who were randomly assigned to treatment with pioglitazone (30 mg/day) or metformin (2000 mg/day) and matching placebo, in addition to glimepiride. At baseline and after 24 weeks of treatment plasma HDL cholesterol levels and CETP mass were measured, and hepatic triglyceride content was assessed by proton magnetic resonance spectroscopy. RESULTS Pioglitazone decreased hepatic triglyceride content (5.9 [interquartile range 2.6–17.4] versus 4.1 [1.9–12.3]%, P < 0.05), decreased plasma CETP mass (2.33 ± 0.10 vs. 2.06 ± 0.10 μg/ml, P < 0.05), and increased plasma HDL cholesterol level (1.22 ± 0.05 vs. 1.34 ± 0.05 mmol/l, P < 0.05). Metformin did not significantly change any of these parameters. CONCLUSIONS A decrease in hepatic triglyceride content by pioglitazone is accompanied by a decrease in plasma CETP mass and associated with an increase in HDL cholesterol levels. These results in patients with type 2 diabetes fully confirm recent findings in mice. |
| تدمد: | 0149-5992 1625-1628 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96c5150416415097d8c85f5d43786ba4Test https://doi.org/10.2337/dc09-1935Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....96c5150416415097d8c85f5d43786ba4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 01495992 16251628 |
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