التفاصيل البيبلوغرافية
| العنوان: |
Dysglycemia and Index60 as Prediagnostic End Points for Type 1 Diabetes Prevention Trials. |
| المؤلفون: |
Nathan, Brandon M., Boulware, David, Geyer, Susan, Atkinson, Mark A., Colman, Peter, Goland, Robin, Russell, William, Wentworth, John M., Wilson, Darrell M., Evans-Molina, Carmella, Wherrett, Diane, Skyler, Jay S., Moran, Antoinette, Sosenko, Jay M., Type 1 Diabetes TrialNet and Diabetes Prevention Trial–Type 1 Study Groups |
| المصدر: |
Diabetes Care; Nov2017, Vol. 40 Issue 11, p1494-1499, 6p |
| مصطلحات موضوعية: |
DIAGNOSIS of diabetes, GLYCEMIC control, BLOOD sugar, BLOOD sugar monitoring, TYPE 2 diabetes, BIOLOGICAL assay, C-peptide, GLUCOSE tolerance tests, LONGITUDINAL method, TYPE 1 diabetes, RESEARCH funding, DIAGNOSIS |
| مستخلص: |
Objective: We assessed dysglycemia and a T1D Diagnostic Index60 (Index60) ≥1.00 (on the basis of fasting C-peptide, 60-min glucose, and 60-min C-peptide levels) as prediagnostic end points for type 1 diabetes among Type 1 Diabetes TrialNet Pathway to Prevention Study participants.Research Design and Methods: Two cohorts were analyzed: 1) baseline normoglycemic oral glucose tolerance tests (OGTTs) with an incident dysglycemic OGTT and 2) baseline Index60 <1.00 OGTTs with an incident Index60 ≥1.00 OGTT. Incident dysglycemic OGTTs were divided into those with (DYS/IND+) and without (DYS/IND-) concomitant Index60 ≥1.00. Incident Index60 ≥1.00 OGTTs were divided into those with (IND/DYS+) and without (IND/DYS-) concomitant dysglycemia.Results: The cumulative incidence for type 1 diabetes was greater after IND/DYS- than after DYS/IND- (P < 0.01). Within the normoglycemic cohort, the cumulative incidence of type 1 diabetes was higher after DYS/IND+ than after DYS/IND- (P < 0.001), whereas within the Index60 <1.00 cohort, the cumulative incidence after IND/DYS+ and after IND/DYS- did not differ significantly. Among nonprogressors, type 1 diabetes risk at the last OGTT was greater for IND/DYS- than for DYS/IND- (P < 0.001). Hazard ratios (HRs) of DYS/IND- with age and 30- to 0-min C-peptide were positive (P < 0.001 for both), whereas HRs of type 1 diabetes with these variables were inverse (P < 0.001 for both). In contrast, HRs of IND/DYS- and type 1 diabetes with age and 30- to 0-min C-peptide were consistent (all inverse [P < 0.01 for all]).Conclusions: The findings suggest that incident dysglycemia without Index60 ≥1.00 is a suboptimal prediagnostic end point for type 1 diabetes. Measures that include both glucose and C-peptide levels, such as Index60 ≥1.00, appear better suited as prediagnostic end points. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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