التفاصيل البيبلوغرافية
| العنوان: |
Type 1 diabetic patients have better endothelial function after simultaneous pancreas–kidney transplantation than after kidney transplantation with continued insulin therapy. |
| المؤلفون: |
Ziaja, Jacek, Kowalik, Adrian P., Kolonko, Aureliusz, Kamińska, Dorota, Owczarek, Aleksander J., Kujawa-Szewieczek, Agata, Kusztal, Mariusz A., Badura, Joanna, Bożek-Pająk, Dominika, Choręza, Piotr, Zakrzewska, Agnieszka, Król, Robert, Chłopicki, Stefan, Klinger, Marian, Więcek, Andrzej, Chudek, Jerzy, Cierpka, Lech |
| المصدر: |
Diabetes & Vascular Disease Research; Mar2018, Vol. 15 Issue 2, p122-130, 9p |
| مستخلص: |
The purpose of this study was to analyse the influence of simultaneous pancreas–kidney or kidney transplantation on endothelial function and systemic inflammation in type 1 diabetic patients with end-stage renal disease. In 39 simultaneous pancreas–kidney, 39 type 1 diabetic kidney and 52 non-diabetic kidney recipients, flow-mediated dilatation was measured. Additionally, blood glycated haemoglobin, serum creatinine and lipids, plasma nitrites ( NO 2 − ) and nitrates, asymmetric dimethylarginine, soluble vascular cell adhesion molecule-1, intercellular adhesion molecule-1, and E-selectin, high-sensitivity C-reactive protein, tumour necrosis factor-α, interleukin 1β and interleukin 6 concentrations were assessed. During 58 ± 31 months follow-up period, flow-mediated dilatation and NO 2 − were greater in simultaneous pancreas–kidney than in type 1 diabetic kidney recipients [10.4% ± 4.7% vs 7.7% ± 4.2%, p < 0.05 and 0.94 (0.74–1.34) vs 0.24 (0.20–0.43) μmol/L, p < 0.01, respectively]. In type 1 diabetic patients after simultaneous pancreas–kidney or kidney transplantation, NO 2 − correlated with flow-mediated dilatation (r = 0.306, p < 0.05) and with blood glycated haemoglobin (r = −0.570, p < 0.001). The difference in NO 2 − was linked to blood glycated haemoglobin and estimated glomerular filtration rate, whereas the difference in flow-mediated dilatation was linked to NO 2 − . The levels of inflammatory markers (except soluble vascular cell adhesion molecule-1) were similar in simultaneous pancreas–kidney and type 1 diabetic kidney recipients. Improved endothelial function in type 1 diabetic patients with end-stage renal disease after simultaneous pancreas–kidney compared to kidney transplantation is associated with normalisation of glucose metabolism but not with improvement in plasma pro-inflammatory cytokines. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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