Elevated levels of insulin-like growth factor-binding protein 1 predict outcome after acute myocardial infarction: A long-term follow-up of the glucose tolerance in patients with acute myocardial infarction (GAMI) cohort
| العنوان: | Elevated levels of insulin-like growth factor-binding protein 1 predict outcome after acute myocardial infarction: A long-term follow-up of the glucose tolerance in patients with acute myocardial infarction (GAMI) cohort |
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| المؤلفون: | Ritsinger, V., Brismar, K., Mellbin, L., Näsman, Per, Rydén, L., Söderberg, S., Norhammar, A. |
| المصدر: | Diabetes & Vascular Disease Research. 15(5):387-395 |
| مصطلحات موضوعية: | abnormal glucose tolerance, Acute myocardial infarction, insulin-like growth factor-binding protein 1, prognosis, glucose, hemoglobin A1c, insulin, lipid, proinsulin, somatomedin binding protein 1, somatomedin C, biological marker, IGFBP1 protein, human, acute heart infarction, adult, aged, all cause mortality, Article, body mass, cancer mortality, cardiovascular mortality, cerebrovascular accident, cohort analysis, controlled study, disease severity, fasting, female, follow up, glucose blood level, glucose tolerance, heart failure, hospital admission, insulin blood level, lipid blood level, long term care, major clinical study, male, outcome assessment, protein blood level, blood, cause of death, chi square distribution, disease exacerbation, heart infarction, Kaplan Meier method, metabolism, middle aged, mortality, neoplasm, proportional hazards model, risk factor, time factor, upregulation, Biomarkers, Blood Glucose, Chi-Square Distribution, Disease Progression, Follow-Up Studies, Humans, Insulin-Like Growth Factor Binding Protein 1, Kaplan-Meier Estimate, Myocardial Infarction, Neoplasms, Proportional Hazards Models, Risk Factors, Time Factors, Up-Regulation |
| الوصف: | Objective: To investigate the long-term prognostic value of insulin-like growth factor-binding protein 1 in patients with acute myocardial infarction. Methods: Patients (n = 180) with admission glucose < 11 mmol/L without previously known diabetes admitted for an acute myocardial infarction in 1998–2000 were followed for mortality and cardiovascular events (first of cardiovascular mortality/acute myocardial infarction/stroke/severe heart failure) until the end of 2011 (median 11.6 years). Fasting levels of insulin-like growth factor-binding protein 1 at day 2 were related to outcome in Cox proportional hazard regression analyses. Results: Median age was 64 years, 69% were male and median insulin-like growth factor-binding protein 1 was 20 µg/L. Total mortality was 34% (n = 61) and 44% (n = 80) experienced a cardiovascular event during a median follow-up time of 11.6 years. After age adjustment, insulin-like growth factor-binding protein 1 was associated with all-cause (1.40; 1.02–1.93, p = 0.039) and cancer mortality (2.09; 1.15–3.79, p = 0.015) but not with cardiovascular death (p = 0.29) or cardiovascular events (p = 0.57). After adjustments also for previous myocardial infarction, previous heart failure and body mass index, insulin-like growth factor-binding protein 1 was still associated with all-cause mortality (1.38; 1.01–1.89, p = 0.046). Conclusion: In patients with acute myocardial infarction without previously known diabetes, high insulin-like growth factor-binding protein 1 was associated with long-term all-cause and cancer mortality but not with cardiovascular events. |
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| الوصول الحر: | https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-236723Test https://doi.org/10.1177/1479164118781892Test |
| قاعدة البيانات: | SwePub |
| تدمد: | 14791641 17528984 |
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| DOI: | 10.1177/1479164118781892 |