المؤلفون: Young-Hwan Park, Minji Sohn, So Yeon Lee, Soo Lim

المصدر: Diabetes & Metabolism Journal, Vol 48, Iss 2, Pp 253-264 (2024)

مصطلحات موضوعية: dipeptidyl-peptidase iv inhibitors, glycated hemoglobin, sodium-glucose transporter 2 inhibitors, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

الوصف: Background We investigated the long-term efficacy and safety of initial triple therapy using metformin, a dipeptidyl peptidase-4 inhibitor, and a sodium-glucose cotransporter-2 inhibitor, in patients with type 2 diabetes mellitus. Methods We enrolled 170 drug-naïve patients with glycosylated hemoglobin (HbA1c) level >7.5% who had started triple therapy (metformin, sitagliptin, and empagliflozin). Glycemic, metabolic, and urinary parameters were measured for 24 months. Results After 24 months, HbA1c level decreased significantly from 11.0%±1.8% to 7.0%±1.7%. At 12 and 24 months, the rates of achievement of the glycemic target goal (HbA1c

وصف الملف: electronic resource

العلاقة: http://e-dmj.org/upload/pdf/dmj-2023-0128.pdfTest; https://doaj.org/toc/2233-6079Test; https://doaj.org/toc/2233-6087Test

الوصول الحر: https://doaj.org/article/375576f8e92f48d39ba038a34123418fTest

المؤلفون: Jun Suh Lee, Minji Sohn, Kyuho Kim, Yoo-Seok Yoon, Soo Lim

المصدر: Diabetes & Metabolism Journal, Vol 47, Iss 5, Pp 703-714 (2023)

مصطلحات موضوعية: diabetes mellitus, pancreatectomy, pancreaticoduodenectomy, quality of life, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

الوصف: Background Long term quality of life is becoming increasingly crucial as survival following partial pancreatectomy rises. The purpose of this study was to investigate the difference in glucose dysregulation after pancreaticoduodenectomy (PD) or distal pancreatectomy (DP). Methods In this prospective observational study from 2015 to 2018, 224 patients who underwent partial pancreatectomy were selected: 152 (67.9%) received PD and 72 (32.1%) received DP. Comprehensive assessment for glucose regulation, including a 75 g oral glucose tolerance test was conducted preoperatively, and 1, 12, and 52 weeks after surgery. Patients were further monitored up to 3 years to investigate development of new-onset diabetes mellitus (NODM) in patients without diabetes mellitus (DM) at baseline or worsening of glucose regulation (≥1% increase in glycosylated hemoglobin [HbA1c]) in those with preexisting DM. Results The disposition index, an integrated measure of β-cell function, decreased 1 week after surgery in both groups, but it increased more than baseline level in the PD group while its decreased level was maintained in the DP group, resulting in a between-group difference at the 1-year examination (P

وصف الملف: electronic resource

العلاقة: http://www.e-dmj.org/upload/pdf/dmj-2022-0205.pdfTest; https://doaj.org/toc/2233-6079Test; https://doaj.org/toc/2233-6087Test

الوصول الحر: https://doaj.org/article/8dc4db7d4298447599fdc26a8d3240a2Test

المؤلفون: Minji Sohn, Hyeyoung Jung, Woo Shun Lee, Tai Hoon Kim, Soo Lim

المصدر: Diabetes & Metabolism Journal, Vol 47, Iss 1, Pp 92-103 (2023)

مصطلحات موضوعية: adiposity, obesity, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

الوصف: Background We investigated whether Lactobacillus plantarum strain LMT1-48, isolated from Korean fermented foods and newborn feces, is a suitable probiotic supplement to treat overweight subjects. Methods In this randomized, double-blind, placebo-controlled clinical trial, 100 volunteers with a body mass index of 25 to 30 kg/m2 were assigned randomly (1:1) to receive 2×1010 colony forming units of LMT1-48 or to a placebo treatment group. Body composition was measured by dual-energy X-ray absorptiometry, and abdominal visceral fat area (VFA) and subcutaneous fat area were measured by computed tomography scanning. Changes in body fat, VFA, anthropometric parameters, and biomarkers were compared between the two treatment groups (ClinicalTrials.gov number: NCT03759743). Results After 12 weeks of treatment, the body weight decreased significantly from 76.6±9.4 to 75.7±9.2 kg in the LMT1-48 group but did not change in the placebo group (P=0.022 between groups). A similar pattern was found in abdominal VFA between the two groups (P=0.041). Serum insulin levels, the corresponding homeostasis model assessment of insulin resistance, and leptin levels decreased in the LMT1-48 group but increased in the placebo group (all P

وصف الملف: electronic resource

العلاقة: http://www.e-dmj.org/upload/pdf/dmj-2021-0370.pdfTest; https://doaj.org/toc/2233-6079Test; https://doaj.org/toc/2233-6087Test

الوصول الحر: https://doaj.org/article/28a71ab0e00140028a75e3b9012449fcTest

المؤلفون: Bo-Yeon Kim, Hyuk-Sang Kwon, Suk Kyeong Kim, Jung-Hyun Noh, Cheol-Young Park, Hyeong-Kyu Park, Kee-Ho Song, Jong Chul Won, Jae Myung Yu, Mi Young Lee, Jae Hyuk Lee, Soo Lim, Sung Wan Chun, In-Kyung Jeong, Choon Hee Chung, Seung Jin Han, Hee-Seok Kim, Ju-Young Min, Sungrae Kim

المصدر: Diabetes & Metabolism Journal, Vol 46, Iss 6, Pp 855-865 (2022)

مصطلحات موضوعية: diabetes mellitus, type 2, lobeglitazone, observational study, thiazolidinediones, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

الوصف: Background Thiazolidinediones (TZDs) have been associated with various safety concerns including weight gain, bladder cancer, and congestive heart failure (CHF). This study evaluated the efficacy and safety of lobeglitazone, a novel TZD in patients with type 2 diabetes mellitus (T2DM) in real practice. Methods In this non-interventional, multi-center, retrospective, and observational study conducted at 15 tertiary or secondary referral hospitals in Korea, a total of 2,228 patients with T2DM who received lobeglitazone 0.5 mg for more than 1 year were enrolled. Results Overall adverse events (AEs) occurred in 381 patients (17.10%) including edema in 1.97% (n=44). Cerebrovascular and cardiovascular diseases were identified in 0.81% (n=18) and 0.81% (n=18), respectively. One case of CHF was reported as an AE. Edema occurred in 1.97% (n=44) of patients. Hypoglycemia occurred in 2.47% (n=55) of patients. Fracture occurred in 1.17% (n=26) of all patients. Lobeglitazone significantly decreased HbA1c level, resulting in a mean treatment difference of −1.05%± 1.35% (P

وصف الملف: electronic resource

العلاقة: http://e-dmj.org/upload/pdf/dmj-2021-0264.pdfTest; https://doaj.org/toc/2233-6079Test; https://doaj.org/toc/2233-6087Test

الوصول الحر: https://doaj.org/article/dd10420617b841838236812117243b0fTest

المؤلفون: Tae Jung Oh, Yeong Gi Kim, Sunyoung Kang, Joon Ho Moon, Soo Heon Kwak, Sung Hee Choi, Soo Lim, Kyong Soo Park, Hak C. Jang, Joon-Seok Hong, Nam H. Cho

المصدر: Diabetes & Metabolism Journal, Vol 43, Iss 3, Pp 342-349 (2019)

مصطلحات موضوعية: diabetes, gestational, diabetes mellitus, type 2, glucose tolerance test, risk factors, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

الوصف: BackgroundWe aimed to identify the postpartum metabolic factors that were associated with the development of diabetes in women with a history of gestational diabetes mellitus (GDM). In addition, we examined the role of the oral glucose tolerance test (OGTT) in the prediction of future diabetes.MethodsWe conducted a prospective study of 179 subjects who previously had GDM but did not have diabetes at 2 months postpartum. The initial postpartum examination including a 75-g OGTT and the frequently sampled intravenous glucose tolerance test (FSIVGTT) was performed 12 months after delivery, and annual follow-up visits were made thereafter.ResultsThe insulinogenic index (IGI30) obtained from the OGTT was significantly correlated with the acute insulin response to glucose (AIRg) obtained from the FSIVGTT. The disposition indices obtained from the OGTT and FSIVGTT were also significantly correlated. Women who progressed to diabetes had a lower insulin secretory capacity including IGI30, AIRg, and disposition indices obtained from the FSIVGTT and OGTT compared with those who did not. However, the insulin sensitivity indices obtained from the OGTT and FSIVGTT did not differ between the two groups. Multivariate logistic regression analysis showed that the 2-hour glucose and disposition index obtained from the FSIVGTT were significant postpartum metabolic risk factors for the development of diabetes.ConclusionWe identified a crucial role of β-cell dysfunction in the development of diabetes in Korean women with previous GDM. The 2-hour glucose result from the OGTT is an independent predictor of future diabetes. Therefore, the OGTT is crucial for better prediction of future diabetes in Korean women with previous GDM.

وصف الملف: electronic resource

العلاقة: http://e-dmj.org/upload/pdf/dmj-43-342.pdfTest; https://doaj.org/toc/2233-6079Test; https://doaj.org/toc/2233-6087Test

الوصول الحر: https://doaj.org/article/45fa01c19a414843824daec5f4499064Test

المؤلفون: Soo Lim, Kyoung Min Kim, Sin Gon Kim, Doo Man Kim, Jeong-Taek Woo, Choon Hee Chung, Kyung Soo Ko, Jeong Hyun Park, Yongsoo Park, Sang Jin Kim, Hak Chul Jang, Dong Seop Choi

المصدر: Diabetes & Metabolism Journal, Vol 41, Iss 5, Pp 377-385 (2017)

مصطلحات موضوعية: Bone density, Diabetes mellitus, type 2, Lobeglitazone, Thiazolidinediones, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

الوصف: BackgroundThe aim of this multicenter, randomized, double-blind study was to examine the effect of lobeglitazone, a novel thiazolidinedione, on the changes in bone mineral density (BMD) in patients with type 2 diabetes mellitus.MethodsA 24-week, double-blinded phase was followed by a 28-week, open-label phase, in which the placebo group also started to receive lobeglitazone. A total of 170 patients aged 34 to 76 years were randomly assigned in a 2:1 ratio to receive lobeglitazone 0.5 mg or a matching placebo orally, once daily. BMD was assessed using dual-energy X-ray absorptiometry at week 24 and at the end of the study (week 52).ResultsDuring the double-blinded phase, the femur neck BMD showed decreasing patterns in both groups, without statistical significance (−0.85%±0.36% and −0.78%±0.46% in the lobeglitazone and placebo groups, respectively). The treatment difference between the groups was 0.07%, which was also not statistically significant. Further, minimal, nonsignificant decreases were observed in both groups in the total hip BMD compared to values at baseline, and these differences also did not significantly differ between the groups. During the open-label phase, the BMD was further decreased, but not significantly, by −0.32% at the femur neck and by −0.60% at the total hip in the lobeglitazone group, and these changes did not significantly differ compared with the original placebo group switched to lobeglitazone.ConclusionOur results indicate that treatment with lobeglitazone 0.5 mg over 52 weeks showed no detrimental effect on the BMD compared to the placebo.

وصف الملف: electronic resource

العلاقة: https://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-41-377.pdfTest; https://doaj.org/toc/2233-6079Test; https://doaj.org/toc/2233-6087Test

الوصول الحر: https://doaj.org/article/39e7387e0b5e445b85ab49e9449b7afaTest

المؤلفون: Young Shin Song, Tae Jung Oh, Kyoung Min Kim, Jae Hoon Moon, Sung Hee Choi, Hak Chul Jang, Kyong Soo Park, Soo Lim

المصدر: Diabetes & Metabolism Journal, Vol 41, Iss 1, Pp 38-50 (2017)

مصطلحات موضوعية: American Heart Association, Atherosclerosis, Cardiovascular disease, Guideline, Korea, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

الوصف: BackgroundThe 2013 American College of Cardiology/American Heart Association (ACC/AHA) guideline for the treatment of blood cholesterol recommends statin therapy for individuals at high risk of atherosclerotic cardiovascular disease (ASCVD). The aim of this study was to investigate serial trends in the percentages of Korean adults considered eligible for statin therapy according to the new ACC/AHA cholesterol guideline.MethodsData from the Korean National Health and Nutrition Examination Survey (KNHANES) I (1998, n=7,698), II (2001, n=5,654), III (2005, n=5,269), IV (2007 to 2009, n=15,727), and V (2010 to 2012, n=16,304), which used a stratified, multistage, probability sampling design, were used as representative of the entire Korean population.ResultsThe percentage of adults eligible for statin therapy according to the ACC/AHA cholesterol guideline increased with time: 17.0%, 19.0%, 20.8%, 20.2%, and 22.0% in KNHANES I, II, III, IV, and V, respectively (P=0.022). The prevalence of ASCVD was 1.4% in KNHANES I and increased to 3.3% in KNHANES V. The percentage of diabetic patients aged 40 to 75 years with a low density lipoprotein cholesterol levels of 70 to 189 mg/dL increased from 4.8% in KNHANES I to 6.1% in KNHANES V. People with an estimated 10-year ASCVD risk ≥7.5% and aged 40 to 75 years accounted for the largest percentage among the four statin benefit groups: 9.1% in KNHANES I and 11.0% in KNHANES V.ConclusionApplication of the 2013 ACC/AHA guideline has found that the percentage of Korean adults in the statin benefit groups has increased over the past 15 years.

وصف الملف: electronic resource

العلاقة: https://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-41-38.pdfTest; https://doaj.org/toc/2233-6079Test; https://doaj.org/toc/2233-6087Test

الوصول الحر: https://doaj.org/article/3d0014fc8d2845f6a883fe98caf74a07Test

المؤلفون: Soo In Choi, Dawn Chung, Jung Soo Lim, Mi Young Lee, Jang Yel Shin, Choon Hee Chung, Ji Hye Huh

المصدر: Diabetes & Metabolism Journal, Vol 41, Iss 1, Pp 51-59 (2017)

مصطلحات موضوعية: Absorptiometry, photon, Body composition, Body fat distribution, Diabetes mellitus, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

الوصف: BackgroundThe aim of this study was to investigate the association between regional body fat distribution, especially leg fat mass, and the prevalence of diabetes mellitus (DM) in adult populations.MethodsA total of 3,181 men and 3,827 postmenopausal women aged 50 years or older were analyzed based on Korea National Health and Nutrition Examination Surveys (2008 to 2010). Body compositions including muscle mass and regional fat mass were measured using dual-energy X-ray absorptiometry.ResultsThe odds ratios (ORs) for DM was higher with increasing truncal fat mass and arm fat mass, while it was lower with increasing leg fat mass. In a partial correlation analysis adjusted for age, leg fat mass was negatively associated with glycosylated hemoglobin in both sexes and fasting glucose in women. Leg fat mass was positively correlated with appendicular skeletal muscle mass and homeostasis model assessment of β cell. In addition, after adjusting for confounding factors, the OR for DM decreased gradually with increasing leg fat mass quartiles in both genders. When we subdivided the participants into four groups based on the median values of leg fat mass and leg muscle mass, higher leg fat mass significantly lowered the risk of DM even though they have smaller leg muscle mass in both genders (P

وصف الملف: electronic resource

العلاقة: https://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-41-51.pdfTest; https://doaj.org/toc/2233-6079Test; https://doaj.org/toc/2233-6087Test

الوصول الحر: https://doaj.org/article/073ff67a3e3c48cd8bf67edf51e752f5Test

المؤلفون: Min Joo Kim, Young Do Koo, Min Kim, Soo Lim, Young Joo Park, Sung Soo Chung, Hak C. Jang, Kyong Soo Park

المصدر: Diabetes & Metabolism Journal, Vol 40, Iss 5, Pp 406-413 (2016)

مصطلحات موضوعية: Ginsenoside Rg3, Mitochondria, Panax, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

الوصف: BackgroundPanax ginseng has glucose-lowering effects, some of which are associated with the improvement in insulin resistance in skeletal muscle. Because mitochondria play a pivotal role in the insulin resistance of skeletal muscle, we investigated the effects of the ginsenoside Rg3, one of the active components of P. ginseng, on mitochondrial function and biogenesis in C2C12 myotubes.MethodsC2C12 myotubes were treated with Rg3 for 24 hours. Insulin signaling pathway proteins were examined by Western blot. Cellular adenosine triphosphate (ATP) levels and the oxygen consumption rate were measured. The protein or mRNA levels of mitochondrial complexes were evaluated by Western blot and quantitative reverse transcription polymerase chain reaction analysis.ResultsRg3 treatment to C2C12 cells activated the insulin signaling pathway proteins, insulin receptor substrate-1 and Akt. Rg3 increased ATP production and the oxygen consumption rate, suggesting improved mitochondrial function. Rg3 increased the expression of peroxisome proliferator-activated receptor γ coactivator 1α, nuclear respiratory factor 1, and mitochondrial transcription factor, which are transcription factors related to mitochondrial biogenesis. Subsequent increased expression of mitochondrial complex IV and V was also observed.ConclusionOur results suggest that Rg3 improves mitochondrial function and the expression of key genes involved in mitochondrial biogenesis, leading to an improvement in insulin resistance in skeletal muscle. Rg3 may have the potential to be developed as an anti-hyperglycemic agent.

وصف الملف: electronic resource

العلاقة: https://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-40-406.pdfTest; https://doaj.org/toc/2233-6079Test; https://doaj.org/toc/2233-6087Test

الوصول الحر: https://doaj.org/article/71c63fc2c1164338b6d0774f57df6dabTest

المؤلفون: Ji Won Yoon, Yong-Chan Ha, Kyoung Min Kim, Jae Hoon Moon, Sung Hee Choi, Soo Lim, Young Joo Park, Jae Young Lim, Ki Woong Kim, Kyong Soo Park, Hak Chul Jang

المصدر: Diabetes & Metabolism Journal, Vol 40, Iss 2, Pp 140-146 (2016)

مصطلحات موضوعية: Aging, Diabetes mellitus, type 2, Muscle, skeletal, Sarcopenia, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

الوصف: BackgroundThe study aimed to investigate the influence of hyperglycemia on muscle quality in older men with type 2 diabetes.MethodsThis was a subsidiary study of the Korean Longitudinal Study of Health and Aging. Among 326 older men consenting to tests of body composition and muscle strength, 269 men were ultimately analyzed after the exclusion because of stroke (n=30) and uncertainty about the diagnosis of diabetes (n=27). Body composition was measured using dual-energy X-ray absorptiometry and computed tomography. Muscle strength for knee extension was measured using an isokinetic dynamometer. Muscle quality was assessed from the ratio of leg strength to the entire corresponding leg muscle mass.ResultsThe muscle mass, strength, and quality in patients with type 2 diabetes did not differ significantly from controls. However, when patients with diabetes were subdivided according to their glycemic control status, patients with a glycosylated hemoglobin (HbA1c) level of ≥8.5% showed significantly decreased leg muscle quality by multivariate analysis (odds ratio, 4.510; P=0.045) after adjustment for age, body mass index, smoking amount, alcohol consumption, physical activity, and duration of diabetes. Physical performance status was also impaired in subjects with an HbA1c of ≥8.5%.ConclusionPoor glycemic control in these older patients with diabetes was associated with significant risk of decreased muscle quality and performance status. Glycemic control with an HbA1c of

وصف الملف: electronic resource

العلاقة: https://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-40-140.pdfTest; https://doaj.org/toc/2233-6079Test; https://doaj.org/toc/2233-6087Test

الوصول الحر: https://doaj.org/article/11a8dd4704a842cf968416631a84c30dTest