Relationship between renal capacity to reabsorb glucose and renal status in patients with diabetes
| العنوان: | Relationship between renal capacity to reabsorb glucose and renal status in patients with diabetes |
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| المؤلفون: | Yawa Abouleka, Ronan Roussel, M. Hallot-Feron, Frédéric Fumeron, Gilberto Velho, Kamel Mohammedi, Odette Matar, Michel Marre, Samy Hadjadj, Louis Potier |
| المساهمون: | UFR de Médecine, Université de Reims Champagne-Ardenne (URCA), Université de Paris (UP), Institut du thorax, Université de Nantes (UN)-IFR26-Institut National de la Santé et de la Recherche Médicale (INSERM), CCSD, Accord Elsevier, Université Paris Cité (UPCité), AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité), Université de Bordeaux (UB), unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), CMC Ambroise Paré [Neuilly-sur-Seine] |
| المصدر: | Diabetes and Metabolism Diabetes and Metabolism, Elsevier Masson, 2020, 46, pp.488-495. ⟨10.1016/j.diabet.2020.03.002⟩ Diabetes & Metabolism Diabetes & Metabolism, 2020, 46, pp.488-495. ⟨10.1016/j.diabet.2020.03.002⟩ |
| بيانات النشر: | Elsevier BV, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Blood Glucose, Male, medicine.medical_specialty, [SDV]Life Sciences [q-bio], Endocrinology, Diabetes and Metabolism, Urology, Renal function, Tubuloglomerular feedback, 030209 endocrinology & metabolism, 030204 cardiovascular system & hematology, Excretion, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Glycosuria, Interquartile range, Diabetes mellitus, Diabetes Mellitus, Internal Medicine, Albuminuria, Humans, Medicine, Diabetic Nephropathies, In patient, Renal Insufficiency, Chronic, Diabetic kidney disease, Aged, Glycated Hemoglobin, Reabsorption, business.industry, General Medicine, Middle Aged, medicine.disease, Renal Reabsorption, [SDV] Life Sciences [q-bio], Diabetes Mellitus, Type 1, Glucose, Diabetes Mellitus, Type 2, Female, business, Glomerular Filtration Rate, Renal glucose transport, Kidney disease |
| الوصف: | International audience; Aims: Interindividual variability in capacity to reabsorb glucose at the proximal renal tubule could contribute to risk of diabetic kidney disease. Our present study investigated, in patients with diabetes, the association between fractional reabsorption of glucose (FRGLU) and degree of renal disease as assessed by urinary albumin excretion (UAE) and estimated glomerular filtration rate (eGFR).Methods: FRGLU [1-(glucose clearance/creatinine clearance)] was assessed in 637 diabetes patients attending our tertiary referral centre, looking for correlations between FRGLU and UAE (normo-, micro-, macro-albuminuria) and Kidney Disease: Improving Global Outcomes (KDIGO) eGFR categories: >90 (G1); 90-60 (G2); 59-30 (G3); and11mmol/L).Results: Median (interquartile range, IQR) FRGLU levels were blood glucose-dependent: 99.90% (0.05) for low (n=106); 99.90% (0.41) for intermediate (n=288); and 96.36% (12.57) for high (n=243) blood glucose categories (P11mmol/L. |
| وصف الملف: | application/pdf |
| تدمد: | 1262-3636 1878-1780 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c765e5a100d9cbfecf4bdbc8a3cff64eTest https://doi.org/10.1016/j.diabet.2020.03.002Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c765e5a100d9cbfecf4bdbc8a3cff64e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 12623636 18781780 |
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