دورية أكاديمية
Clinical and metabolic characteristics of patients with latent autoimmune diabetes in adults (LADA): absence of rapid beta-cell loss in patients with tight metabolic control
| العنوان: | Clinical and metabolic characteristics of patients with latent autoimmune diabetes in adults (LADA): absence of rapid beta-cell loss in patients with tight metabolic control |
|---|---|
| المؤلفون: | L. Chaillous, B. Bouhanick, V. Kerlan, E. Mathieu, P. Lecomte, P.H. Ducluzeau-Fieloux, M. Delamaire, E. Sonnet, D. Maugendre, R. Maréchaud, V. Rohmer, P. Saï, B. Charbonnel |
| المصدر: | Diabetes & metabolism |
| بيانات النشر: | Elsevier Masson |
| سنة النشر: | 2010 |
| المجموعة: | Université Angers: Okina (Open Knowledge, INformation, Access) |
| مصطلحات موضوعية: | Adult, Age of Onset, Aged, Biological Markers, Blood Glucose, Body Mass Index, C-Peptide, Cross-Sectional Studies, Diabetes Mellitus, Type 1, Disease Progression, Female, Humans, Hypoglycemic Agents, Insulin, Insulin-Secreting Cells, Male, Middle Aged, Prospective Studies |
| الوصف: | AIM AND METHODS: The present study compared the clinical and metabolic characteristics of latent autoimmune diabetes in adults (LADA) with type 2 diabetes, as well as the residual beta-cell function and progression to insulin treatment, over a 2-year follow-up period, of antibody (Ab)-positive and Ab-negative patients who achieved tight glycaemic control (HbA(1c) 7.0+/-0.8% and 6.5+/-0.9%, respectively, at the time of entry into the study). RESULTS: Glutamic acid decarboxylase antibodies (GADA) and/or islet cell antibodies (ICA) were detected in 10% of patients presenting with non-insulin-dependent diabetes. Around half of Ab-positive patients required insulin treatment during the follow-up. Ab-positive patients displayed lower stimulated C-peptide levels both at entry and during the follow-up compared with Ab-negative patients, although no significant decline in C-peptide levels was observed in either subgroup over two years. Nevertheless, Ab-positive patients progressed more frequently to insulin treatment, and stimulated C-peptide tended to decrease in LADA patients who subsequently required insulin, whereas it remained stable in those who were non-insulin-dependent. In those who progressed, the trend towards C-peptide decline persisted even after starting insulin treatment. CONCLUSION: LADA patients demonstrate lower residual beta-cell function than do type 2 diabetes patients. However, those who achieve tight metabolic control do not present with a rapid decline in beta-cell function. Further studies are needed to determine the optimal treatment strategy in such patients. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | http://okina.univ-angers.fr/publications/ua246Test |
| DOI: | 10.1016/j.diabet.2009.07.004 |
| الإتاحة: | https://doi.org/10.1016/j.diabet.2009.07.004Test http://okina.univ-angers.fr/publications/ua246Test |
| رقم الانضمام: | edsbas.55290A9D |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.diabet.2009.07.004 |
|---|