المؤلفون: Aleksandra Uruska, Anita Kaczmarek, Wiktoria Ciepłucha, Justyna Flotyńska, Aleksandra Nowicka, Kamila Jaz, Aleksandra Cieluch, Dorota Zozulińska-Ziółkiewicz, Agata Grzelka-Woźniak, Aleksandra Pypeć

المصدر: Diabetes/Metabolism Research and Reviews. 38

مصطلحات موضوعية: Adult, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Population, Logistic regression, Endocrinology, Statistical significance, Diabetes mellitus, Internal medicine, Internal Medicine, Humans, Insulin, Medicine, Prospective Studies, education, Exercise, Type 1 diabetes, education.field_of_study, C-Peptide, business.industry, Remission Induction, VO2 max, medicine.disease, Confidence interval, Diabetes Mellitus, Type 1, Observational study, business

الوصف: AIM To investigate whether physical activity is associated with the occurrence of remission in adults with type 1 diabetes. METHODS Ninety nine adult participants with newly diagnosed type 1 diabetes were enroled into a prospective, observational study. The participants were advised to exercise 2-3 times a week with moderate intensity for a one-year period. Physical activity was assessed by a self-administrated questionnaire on every fourth visit. We counted the months in which participants fulfiled a partial-remission criteria: HbA1c 0.5 ng/ml, and daily dose of insulin

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5a3d122592e4e0a7e8348288625800dTest
https://doi.org/10.1002/dmrr.3510Test

المؤلفون: Marga Giménez, Irene Vinagre, Eva Meler, Ignacio Conget, Antonio J. Amor, Verónica Perea, Eva López, Xavier Urquizu, Laura Codina, Maria J. Barahona, Carmen Quirós, Maite Valverde

المصدر: Diabetes/Metabolism Research and Reviews. 37

مصطلحات موضوعية: Adult, Carotid Artery Diseases, Very low-density lipoprotein, Lipoproteins, Endocrinology, Diabetes and Metabolism, Population, 030209 endocrinology & metabolism, 030204 cardiovascular system & hematology, Preeclampsia, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, Nuclear magnetic resonance, Pre-Eclampsia, Pregnancy, Diabetes mellitus, Internal Medicine, medicine, Humans, education, Nuclear Magnetic Resonance, Biomolecular, Type 1 diabetes, education.field_of_study, Eclampsia, Triglyceride, business.industry, nutritional and metabolic diseases, Middle Aged, medicine.disease, Diabetes Mellitus, Type 1, chemistry, Female, lipids (amino acids, peptides, and proteins), business, Biomarkers, Lipoprotein

الوصف: AIMS Persistence of lipoprotein abnormalities in type 1 diabetes (T1D) and/or pre-eclampsia could be associated with cardiovascular disease (CVD). We assessed differences in the advanced lipoprotein profiles according to the presence of both conditions and their differential association with atherosclerosis. MATERIAL AND METHODS We recruited 112 women without CVD and last pregnancy ≥5 years previously, divided into four groups (n = 28 per group): (a) T1D and previous pre-eclampsia; (b) T1D without pre-eclampsia; (c) pre-eclampsia without T1D; and (d) controls (without T1D/pre-eclampsia). Groups were matched by several risk factors, and diabetes duration and retinopathy in T1D. Carotid intima-media thickness (IMT) and the presence of plaque (IMT ≥1.5 mm) were assessed by ultrasonography. The lipoprotein profile was evaluated by nuclear magnetic resonance (NMR) spectroscopy. RESULTS The participants were 44.9 ± 7.8 years old. Carotid plaque presence was 20.5%, with a higher prevalence in T1D and/or pre-eclampsia vs controls (P

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::719cf00759798b8846d1dd7ecd899062Test
https://doi.org/10.1002/dmrr.3362Test

المؤلفون: Lina Zhang, Zhi Chen, Jingwen Fan, Xiaoye Duan, Lixin Guo, Qi Pan, Weihao Wang, Xiaobei Pei, Dong Lin

المصدر: Diabetes/Metabolism Research and Reviews. 37

مصطلحات موضوعية: Adult, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Population, 030209 endocrinology & metabolism, 030204 cardiovascular system & hematology, Tertiary care, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Insulin resistance, Risk Factors, Internal medicine, Diabetes mellitus, Diabetes Mellitus, Internal Medicine, medicine, Humans, Adult Onset Diabetes, Family history, education, Glycated Hemoglobin, Inpatients, education.field_of_study, Diabetic Retinopathy, business.industry, Diabetic retinopathy, medicine.disease, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, business, Body mass index

الوصف: BACKGROUND To determine whether the new international cluster-based classification method can be applied to Chinese inpatients with diabetes mellitus (DM). METHODS Adult patients with DM hospitalized in our tertiary care centre from January 2017 to December 2018 were included in the study. K-means cluster analysis was done in clusters based on glutamic acid decarboxylase antibodies, body mass index, glycosylated haemoglobin, homeostasis model-assessed beta cell function, insulin resistance index, and age at diagnosis of DM. Chi-square test was used to analyse inter-subgroup differences in DM-related complications and family history of DM. p

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e83c04e6bb5803c1de0a68c18b4bba9aTest
https://doi.org/10.1002/dmrr.3427Test

المؤلفون: Lucinda Green, Michael D. Feher, Jose Catalan

المصدر: Diabetes/Metabolism Research and Reviews. 16:287-293

مصطلحات موضوعية: Adult, Blood Glucose, Male, Automobile Driving, medicine.medical_specialty, endocrine system diseases, Endocrinology, Diabetes and Metabolism, Population, Poison control, Phobic disorder, Endocrinology, mental disorders, Internal Medicine, Humans, Medicine, Psychiatry, education, Agoraphobia, education.field_of_study, Phobias, business.industry, Panic disorder, nutritional and metabolic diseases, Fear, medicine.disease, Hypoglycemia, Diabetes Mellitus, Type 1, Panic Disorder, Anxiety, medicine.symptom, business, hormones, hormone substitutes, and hormone antagonists, Anxiety disorder

الوصف: Phobic disorders are more common in people with diabetes than in the general population. The management of phobic disorders in patients with diabetes, particularly when associated with a fear of hypoglycaemia, is especially challenging and requires close collaboration between psychological medicine and diabetes teams. Difficulty in distinguishing symptoms of anxiety from those of hypoglycaemia, and the real dangers associated with hypoglycaemia, complicate the delivery of psychological interventions that are used routinely in the treatment of phobias. Avoidance of hypoglycaemia can lead to deterioration in diabetes control. This case report describes a man with Type 1 diabetes who developed agoraphobia with panic disorder, associated with fear of hypoglycaemia and deterioration in glycaemic control. The management of patients with diabetes and phobic disorders, with particular reference to those associated with fear of hypoglycaemia, is discussed.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0531418ef66f0cc061dd65ca56daf23dTest
https://doi.org/10.1002/1520-7560Test(2000)9999:9999<::aid-dmrr123>3.0.co;2-t

المؤلفون: Joachim Rosenbauer, Guido Giani, P. Herzig

المصدر: Diabetes/metabolism research and reviews. 24(3)

مصطلحات موضوعية: Adult, Pediatrics, medicine.medical_specialty, Diabetes risk, Adolescent, Endocrinology, Diabetes and Metabolism, Birth weight, Population, Breastfeeding, Paternal Age, Endocrinology, Reference Values, Germany, Surveys and Questionnaires, Internal Medicine, medicine, Humans, Risk factor, Age of Onset, education, Child, Type 1 diabetes, education.field_of_study, business.industry, Infant, medicine.disease, Low birth weight, Breast Feeding, Diabetes Mellitus, Type 1, Case-Control Studies, Child, Preschool, Infant Food, medicine.symptom, business, Breast feeding, Maternal Age

الوصف: The evidence on the role of environmental factors in the development of type 1 diabetes is conflicting. Reducing potential bias and the variety of exposures, we investigated the association between type 1 diabetes risk and nutritional and environmental exposures in pre-school children.This nationwide population-based case-control study included 760 cases under 5 years of age newly diagnosed with type 1 diabetes during 1992-1995. From the general population, 1,871 controls were randomly selected and individually matched on age ( +/- 1 year), sex, and residence. Information on infant diet, foetal, perinatal and socio-economic factors, and familial diabetes was obtained by a parent-administered questionnaire. Data were analysed by multiple conditional logistic regression.Duration of breastfeeding and age at introduction of bottle-feeding were inversely associated with type 1 diabetes risk according to a dose-response relationship (trend test p0.05). Adjusted odd ratios (95% CI) for a long breastfeeding period and a late introduction of bottle-feeding (or=5 month versus2 weeks) were 0.71 (0.54-0.93) and 0.80 (0.62-1.04), respectively. Familial type 1 diabetes, maternal age40 years, and low birth weight were found more frequently among diabetic than among control children. Current cow's milk consumption, higher social status, and a larger family were associated with a reduced diabetes risk. Up to one half of the diabetic cases in the population could be attributed to modifiable exposures.Our findings indicate that infant feeding is associated with type 1 diabetes risk and that a considerable part of new type 1 diabetic cases is potentially preventable.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c939da3c89597e59b5841fc69b559efTest
https://pubmed.ncbi.nlm.nih.gov/17968982Test

المؤلفون: Jan W. Eriksson, Mona Landin-Olsson, Bengt Littorin, Lennarth Nyström, Bengt Scherstén, Jan Bolinder, Åke Lernmark, Göran Sundkvist, Carina Törn, Göran Blohmé, Jan Östman, Elisabeth Björk, Hans J. Arnqvist

المصدر: Diabetes/metabolism research and reviews. 16(6)

مصطلحات موضوعية: Adult, medicine.medical_specialty, Adolescent, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Glutamate decarboxylase, Population, Type 2 diabetes, Gastroenterology, Body Mass Index, Diagnosis, Differential, chemistry.chemical_compound, Islets of Langerhans, Endocrinology, Predictive Value of Tests, Diabetes mellitus, Internal medicine, Internal Medicine, medicine, Humans, Hypoglycemic Agents, Insulin, education, Autoantibodies, Sweden, education.field_of_study, Type 1 diabetes, C-Peptide, C-peptide, business.industry, Glutamate Decarboxylase, Autoantibody, medicine.disease, Isoenzymes, Diabetes Mellitus, Type 1, chemistry, Diabetes Mellitus, Type 2, business

الوصف: Background Differentiation between Type 1 and Type 2 diabetes in adults is difficult at diagnosis. In this study we tested the hypothesis that autoantibodies at diagnosis are predictive for insulin treatment within 3 years in patients initially not classified as Type 1 diabetes. Methods In a nationwide population-based study, blood samples were obtained from 764 patients, all diagnosed with diabetes during a 2-year period. At diagnosis, 583 (76%) were classified as Type 1, 110 (14%) as Type 2 and 71 (9.3%) could not be classified. Results Among patients not classified as Type 1 diabetes, 52 (47%) of Type 2 and 42 (59%) of unclassified patients were positive for islet cell antibodies CICA), glutamic acid decarboxylase antibodies (GADA) or tyrosine phosphatase antibodies (IA-2A). These patients (n=94) had lower body mass index (BMI) (p

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16c0fc5ec16834861eecd0c0d68c9244Test
https://pubmed.ncbi.nlm.nih.gov/11114103Test

المؤلفون: Yongsoo Park, Jungtaek Woo, Munsuk Nam, Leejin Park, Sangmo Hong, Young-Seol Kim, Sehyun Baik, Kwan Woo Lee

المصدر: Diabetes/metabolism research and reviews. 27(8)

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Population, Type 2 diabetes, Zinc Transporter 8, Endocrinology, Insulin resistance, Asian People, Diabetes mellitus, Internal medicine, Internal Medicine, medicine, Prevalence, Humans, Insulin, Prospective Studies, education, Cation Transport Proteins, Aged, Autoantibodies, education.field_of_study, Korea, business.industry, Glutamate Decarboxylase, Incidence (epidemiology), Autoantibody, Middle Aged, medicine.disease, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Immunology, Cohort, Disease Progression, Female, Insulin Resistance, business, Follow-Up Studies

الوصف: Background Latent autoimmune diabetes in adults (LADA) is a form of autoimmune-mediated diabetes in adults, usually defined by GAD autoantibody positivity. Few epidemiological surveys on LADA in Asians did not come to a conclusive answer regarding prevalence and incidence, because of different criteria used in patient ascertainment. Methods We estimated LADA prevalence in a recent type 2 diabetes cohort by the positivity of circulating autoantibodies to pancreatic islet cell antigens (GAD, IA-2 and zinc transporter 8 (ZnT8)) applying a comparable Caucasian criteria. We then observed the development of insulin dependency prospectively for 36 months. Results Applying the European NIRAD LADA group criteria, we found a high prevalence of LADA (4.4%) in Korean patients with phenotypic type 2 diabetes. This high prevalence of LADA in Korea is noteworthy since the previous population-based LADA prevalence survey reported low prevalence (1.7%). When we consider the low-titre GAD antibodies and the low prevalence of multiple autoantibodies, however, increased LADA prevalence does not necessarily mean increase in future insulin dependency. After 36 months of follow-up, only 3 of 39 patients who were initially classified as LADA have become insulin-dependent. Those three were all positive for multiple autoantibodies (GAD, IA-2 and zinc transporter 8 antibody). Other features of insulin secretion or insulin resistance did not determine future insulin necessity. Conclusions Although the LADA prevalence estimated by anti-GAD positivity appeared to increase, the true insulin dependency evidenced by multiple antibody positivity did not increase in Korea. Copyright © 2011 John Wiley & Sons, Ltd.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13ca3049e39d7646af1561159b6d3e0bTest
https://pubmed.ncbi.nlm.nih.gov/22069296Test

المؤلفون: Jean-Christophe Philips, Monique Marchand, André Scheen

المصدر: Diabetes/metabolism research and reviews. 25(5)

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Time Factors, Arteriosclerosis, Endocrinology, Diabetes and Metabolism, Population, Diastole, Hemodynamics, Blood Pressure, Baroreflex, Autonomic Nervous System, Cardiovascular System, Young Adult, Endocrinology, Diabetic Neuropathies, Reference Values, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, Humans, education, education.field_of_study, Analysis of Variance, business.industry, Middle Aged, medicine.disease, Pulse pressure, Blood pressure, Cross-Sectional Studies, Diabetes Mellitus, Type 1, Cardiovascular Diseases, Case-Control Studies, Cardiology, Arterial stiffness, Female, business, Diabetic Angiopathies

الوصف: Background To evaluate changes in pulse pressure (PP) and markers of cardiovascular autonomic neuropathy (CAN) according to duration of type 1 diabetes mellitus (T1DM). Methods This cross-sectional controlled study evaluated 159 diabetic patients during a 3-min posture test (standing-squatting-standing) with continuous measurement of systolic (SBP), diastolic (DBP) and mean (MBP) blood pressure by a Finapres device. Arterial stiffness was indirectly assessed by PP and the slope of PP as a function of MBP calculated during the whole 3-min test. CAN was assessed by the expiration/inspiration pulse interval ratio (E/I R-R ratio) during deep breathing and by three indices measured during the squatting test. Patients were divided into four groups according to diabetes duration ( 30 years from group 1 to group 4, respectively) and compared with age-matched non-diabetic subjects. Results PP progressively increased (p < 0.0001) and PP/MBP decreased (p < 0.0005) according to T1DM duration, whereas these parameters remained almost unchanged in age-matched control subjects. E/I ratio (p < 0.0001) and baroreflex gain (p < 0.0005) progressively decreased with T1DM duration. The parasympathetic index (squatting test vagal ratio - SqTv) significantly increased (p < 0.0001), whereas the sympathetic index (squatting test sympathetic ratio - SqTs) only tended to decrease (p = 0.12) according to diabetes duration. No such changes in CAN indices were observed in the non-diabetic population. Conclusions PP increased according to T1DM duration in an age range where PP remained almost stable in controls, in agreement with accelerated arterial stiffening due to chronic hyperglycaemia. The baroreflex gain decreased and other indices of CAN also deteriorated with diabetes duration, more so indices reflecting parasympathetic rather than sympathetic dysfunction.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78022e09756d2570098470d2f72c1f47Test
https://pubmed.ncbi.nlm.nih.gov/19437445Test

المؤلفون: M. D. José Antonio González-Correa, M. D. José Pedro De La Cruz, M. D. Ana Guerrero, M. D. Felipe Sánchez de la Cuesta

المصدر: Diabetes/metabolism research and reviews. 20(2)

مصطلحات موضوعية: Adult, Blood Glucose, Vascular Endothelial Growth Factor A, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Population, Ophthalmologic Surgical Procedures, Bioinformatics, Eye, Antioxidants, Retina, chemistry.chemical_compound, Endocrinology, Diabetes mellitus, Internal medicine, Internal Medicine, medicine, Animals, Humans, Endothelial dysfunction, Enzyme Inhibitors, education, Aged, education.field_of_study, Diabetic Retinopathy, Laser Coagulation, business.industry, Endothelial Cells, Diabetic retinopathy, Middle Aged, medicine.disease, Vascular endothelial growth factor, Diabetes Mellitus, Type 1, chemistry, Diabetes Mellitus, Type 2, Hyperglycemia, Vitreous hemorrhage, business, Laser coagulation, Platelet Aggregation Inhibitors, Retinopathy

الوصف: Diabetic retinopathy is the most frequent cause of legal blindness in the population of 30-to-70-year olds. Whether retinopathy appears or not depends mainly on the duration of the disease and the degree of metabolic control the patient maintains. High blood glucose values lead to important changes in cellular metabolism and the main effects of these alterations are endothelial dysfunction that sets in motion the morphological process of diabetic retinopathy. The biochemical lesions caused by prolonged hyperglycemia can be positively influenced, but usually not normalized, pharmacologically with some groups of drugs, which are now under development. This makes tight control of glycemia a key measure in preventing the onset or progression of diabetic retinopathy, together with an effective program of ophthalmologic detection and follow-up in patients with diabetes. Regarding the role of endothelial dysfunction, antiplatelet drugs have been shown to slow some aspects of the evolution of diabetic retinopathy in its initial stages, mainly a lower degree of microaneurysms. However, a new approach to controlling endothelial dysfunction shows promise, mainly through the vascular endothelial growth factor (VEGF) inhibitors. These agents may prove to be especially useful in the treatment of proliferative diabetic retinopathy. Other encouraging results have been obtained in studies of antioxidant drugs and inhibitors of the formation of advanced glycation end products. Once retinal lesions appear, preventive measures need to be redoubled, with special attention to controlling glycemia; however, it is also necessary to resort to laser photocoagulation. This intervention aims to eliminate areas of ischemia and to diminish the formation of retinal exudates. If this measure fails or if vitreous hemorrhage appears, the only remaining therapeutic measure is vitrectomy.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27cc0033456eeae915e048d17b836eadTest
https://pubmed.ncbi.nlm.nih.gov/15037985Test

المؤلفون: G. F. Bottazzo, M. L. Del Buono, U. Di Mario, Mattia Locatelli, G. Multari, Renata Lorini, Franco Meschi, Teodorica L. Bugawan, Henry A. Erlich, Raffaella Buzzetti, Andrea Galgani, Antonio Petrone, Paolo Pozzilli

المصدر: Diabetes/metabolism research and reviews. 20(2)

مصطلحات موضوعية: musculoskeletal diseases, Adult, Genetic Markers, Male, medicine.medical_specialty, endocrine system diseases, Endocrinology, Diabetes and Metabolism, Population, Statistics, Nonparametric, Endocrinology, immune system diseases, Risk Factors, Internal medicine, HLA-DQ Antigens, Genotype, Internal Medicine, medicine, HLA-DQ beta-Chains, Humans, Genetic Predisposition to Disease, Genetic Testing, Risk factor, skin and connective tissue diseases, education, Genetic testing, Genetics, education.field_of_study, Chi-Square Distribution, medicine.diagnostic_test, business.industry, Histocompatibility Testing, Incidence, Absolute risk reduction, Case-control study, Infant, Newborn, nutritional and metabolic diseases, Odds ratio, HLA-DR Antigens, Genotype frequency, Diabetes Mellitus, Type 1, Italy, Case-Control Studies, Female, business, HLA-DRB1 Chains

الوصف: Background To develop a sensitive, specific screening strategy for predicting genetic risk for type 1 diabetes mellitus (T1DM) in the low-incidence continental Italian population, and to define with this tool, a cohort of high-to-moderate risk infants for an immunological follow-up study aimed at identifying environmental risk factors for T1DM. Methods 4855 newborns in three regions of continental Italy were screened for T1DM HLA-DRB1-DQB1 risk genotypes using a reverse line blot typing method. Risk classification was based on odds ratios (OR) found in a preliminary case–control study (356 T1DM patients, 412 controls). Screening efficiency was optimized by allele subtyping. Results Screening for well-known T1DM susceptibility genotypes [DRB1*03/*04-DQB1*0302; DRB1*03/*03; DRB1*04/*04-DQB1*0302; DRB1*04-DQB1*0302/X where X ≠ DRB1*03, DRB1*04-DQB1*0302, DQB1*0602 or DQB1*0603] was associated with

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3320a67fc3feb28d9668004fcf26b83dTest
https://pubmed.ncbi.nlm.nih.gov/15037989Test