Alloantibody and Autoantibody Monitoring Predicts Islet Transplantation Outcome in Human Type 1 Diabetes
| العنوان: | Alloantibody and Autoantibody Monitoring Predicts Islet Transplantation Outcome in Human Type 1 Diabetes |
|---|---|
| المؤلفون: | Vito Lampasona, Marina Scavini, Matthew J Everly, Mario Scalamogna, Antonio Secchi, Emanuele Bosi, Paul I. Terasaki, Ezio Bonifacio, Massimo Cardillo, Francesca Poli, Paola Maffi, Alessia Mercalli, Rita Nano, Alejandro Espadas de Arias, Valeria Sordi, Raffaella Melzi, Lorenzo Piemonti |
| المساهمون: | Piemonti, Lorenzo, Everly, Mj, Maffi, P, Scavini, M, Poli, F, Nano, R, Cardillo, M, Melzi, R, Mercalli, A, Sordi, V, Lampasona, V, de Arias, Ae, Scalamogna, M, Bosi, Emanuele, Bonifacio, E, Secchi, Antonio, Terasaki, Pi |
| المصدر: | Diabetes |
| بيانات النشر: | American Diabetes Association, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Adult, Male, endocrine system, Endocrinology, Diabetes and Metabolism, Islets of Langerhans Transplantation, 030209 endocrinology & metabolism, 030230 surgery, medicine.disease_cause, Autoimmunity, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Immune system, Antigen, Isoantibodies, Monitoring, Immunologic, Internal Medicine, medicine, Humans, Survival analysis, Antilymphocyte Serum, Original Research, Autoantibodies, Immunosuppression Therapy, Sirolimus, geography, geography.geographical_feature_category, biology, business.industry, Graft Survival, Autoantibody, Middle Aged, Mycophenolic Acid, Prognosis, Islet, Survival Analysis, 3. Good health, Transplantation, Diabetes Mellitus, Type 1, Immunology, Commentary, biology.protein, Female, Immunology and Transplantation, Antibody, business, Biomarkers, Immunosuppressive Agents, Follow-Up Studies |
| الوصف: | Long-term clinical outcome of islet transplantation is hampered by the rejection and recurrence of autoimmunity. Accurate monitoring may allow for early detection and treatment of these potentially compromising immune events. Islet transplant outcome was analyzed in 59 consecutive pancreatic islet recipients in whom baseline and de novo posttransplant autoantibodies (GAD antibody, insulinoma-associated protein 2 antigen, zinc transporter type 8 antigen) and donor-specific alloantibodies (DSA) were quantified. Thirty-nine recipients (66%) showed DSA or autoantibody increases (de novo expression or titer increase) after islet transplantation. Recipients who had a posttransplant antibody increase showed similar initial performance but significantly lower graft survival than patients without an increase (islet autoantibodies P < 0.001, DSA P < 0.001). Posttransplant DSA or autoantibody increases were associated with HLA-DR mismatches (P = 0.008), induction with antithymocyte globulin (P = 0.0001), and pretransplant panel reactive alloantibody >15% in either class I or class II (P = 0.024) as independent risk factors and with rapamycin as protective (P = 0.006) against antibody increases. DSA or autoantibody increases after islet transplantation are important prognostic markers, and their identification could potentially lead to improved islet cell transplant outcomes. |
| تدمد: | 1939-327X 0012-1797 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5b20bd6639ff0fa80b06516fe6e9dffTest https://doi.org/10.2337/db12-1258Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c5b20bd6639ff0fa80b06516fe6e9dff |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1939327X 00121797 |
|---|