Hepatic Extraction of Plasma Immunoreactive Glucagon Components: Predilection for 3500-dalton Glucagon Metabolism by the Liver
| العنوان: | Hepatic Extraction of Plasma Immunoreactive Glucagon Components: Predilection for 3500-dalton Glucagon Metabolism by the Liver |
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| المؤلفون: | Kenneth S. Polonsky, J B Field, Jonathan B. Jaspan, Toshihiko Ishida, S Röjdmark, Arthur H. Rubenstein |
| المصدر: | Diabetes. 30:767-772 |
| بيانات النشر: | American Diabetes Association, 1981. |
| سنة النشر: | 1981 |
| مصطلحات موضوعية: | medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Extraction (chemistry), Size-exclusion chromatography, Radioimmunoassay, Biological activity, Metabolism, Hepatic Veins, Biology, Arginine, Glucagon, Molecular Weight, Kinetics, Portal System, Dogs, Hepatic Artery, Endocrinology, Liver, Internal medicine, Internal Medicine, medicine, Hepatic extraction, Animals |
| الوصف: | This Study examines quantitatively the extraction of plasma immunoreactive glucagon (IRG) components by the liver. It was shown that the liver has a predilection for removal of the 3500-dalton biologically active IRG component with virtually no extraction of the other IRG fractions. Hepatic extraction of whole plasma IRG was 25.2 ± 2.5%. Analysis of the hepatic extraction of the four plasma immunoreactive components, separated by gel filtration, revealed variable but quantitatively insignificant extraction of all components other than the 3500-dalton fraction, which was 33.4 ± 3.2% (P < 0.001). Hepatic extraction of whole plasma IRG was significantly less than that of the 3500-dalton component during periods of basal glucagon secretion when IRG fractions other than the 3500-dalton fraction contribute substantially to the whole plasma IRG level. However, during periods of stimulation of glucagon secretion by arginine or arginine plus cholecystokinin-pancreozymin, when the 3500-dalton component accounts for virtually all of the whole plasma IRG level, hepatic extraction of whole plasma IRG was similar to that of the 3500-dalton fraction. |
| تدمد: | 1939-327X 0012-1797 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5d78e44a52138af028fff712ffb49a0Test https://doi.org/10.2337/diab.30.9.767Test |
| رقم الانضمام: | edsair.doi.dedup.....a5d78e44a52138af028fff712ffb49a0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1939327X 00121797 |
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