Cumulative Risk, Age at Onset, and Sex-Specific Differences for Developing End-Stage Renal Disease in Young Patients With Type 1 Diabetes
| العنوان: | Cumulative Risk, Age at Onset, and Sex-Specific Differences for Developing End-Stage Renal Disease in Young Patients With Type 1 Diabetes |
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| المؤلفون: | Hans J. Arnqvist, Lennarth Nyström, Maria Svensson, Gisela Dahlquist, Yonas Berhan, Ingeborg Waernbaum, Staffan Schön, Anna Möllsten |
| المصدر: | Diabetes |
| بيانات النشر: | American Diabetes Association, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Adult, Male, Risk, medicine.medical_specialty, Pediatrics, Complications, Adolescent, Endocrinology, Diabetes and Metabolism, Population, Kaplan-Meier Estimate, Risk Assessment, End stage renal disease, Cohort Studies, Sex Factors, Risk Factors, Internal Medicine, medicine, Humans, Cumulative incidence, Diabetic Nephropathies, Registries, Risk factor, Age of Onset, education, Child, Sweden, education.field_of_study, Type 1 diabetes, business.industry, Incidence, Infant, medicine.disease, Surgery, Diabetes Mellitus, Type 1, Child, Preschool, Cohort, Kidney Failure, Chronic, Female, Age of onset, business, Cohort study |
| الوصف: | OBJECTIVE This study aimed to estimate the current cumulative risk of end-stage renal disease (ESRD) due to diabetic nephropathy in a large, nationwide, population-based prospective type 1 diabetes cohort and specifically study the effects of sex and age at onset. RESEARCH DESIGN AND METHODS In Sweden, all incident cases of type 1 diabetes aged 0–14 years and 15–34 years are recorded in validated research registers since 1977 and 1983, respectively. These registers were linked to the Swedish Renal Registry, which, since 1991, collects data on patients who receive active uremia treatment. Patients with ≥13 years duration of type 1 diabetes were included (n = 11,681). RESULTS During a median time of follow-up of 20 years, 127 patients had developed ESRD due to diabetic nephropathy. The cumulative incidence at 30 years of type 1 diabetes duration was low, with a male predominance (4.1% [95% CI 3.1–5.3] vs. 2.5% [1.7–3.5]). In both male and female subjects, onset of type 1 diabetes before 10 years of age was associated with the lowest risk of developing ESRD. The highest risk of ESRD was found in male subjects diagnosed at age 20–34 years (hazard ratio 3.0 [95% CI 1.5–5.7]). In female subjects with onset at age 20–34 years, the risk was similar to patients' diagnosed before age 10 years. CONCLUSIONS The cumulative incidence of ESRD is exceptionally low in young type 1 diabetic patients in Sweden. There is a striking difference in risk for male compared with female patients. The different patterns of risk by age at onset and sex suggest a role for puberty and sex hormones. |
| اللغة: | English |
| تدمد: | 1939-327X 0012-1797 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d2ef91efa5c084c80d42c6c59105f1aTest http://europepmc.org/articles/PMC2889782Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2d2ef91efa5c084c80d42c6c59105f1a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1939327X 00121797 |
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