دورية أكاديمية
Corneal confocal microscopy detects early nerve regeneration in diabetic neuropathy after simultaneous pancreas and kidney transplantation
| العنوان: | Corneal confocal microscopy detects early nerve regeneration in diabetic neuropathy after simultaneous pancreas and kidney transplantation |
|---|---|
| المؤلفون: | Tavakoli, Mitra, Mitu-Pretorian, Maria, Petropoulos, Ioannis, Fadavi, Hassan, Asghar, Omar, Alam, Uazman, Ponirakis, Georgios, Jeziorska, Maria, Marshall, Andrew, Efron, Nathan, Boulton, Andrew, Augustine, Titus, Malik, Rayaz |
| المصدر: | Diabetes |
| بيانات النشر: | American Diabetes Association Inc. |
| سنة النشر: | 2013 |
| المجموعة: | Queensland University of Technology: QUT ePrints |
| مصطلحات موضوعية: | Kidney Transplantation, Nerve Regeneration, Pancreas Transplantation, Adult, Confocal, Cornea/*innervation/pathology, Diabetes Mellitus, Diabetic Neuropathies/*physiopathology/surgery, Female, Humans, Male, Microscopy, Middle Aged, Neural Conduction, Type 1/*complications/physiopathology |
| الوصف: | Diabetic neuropathy is associated with increased morbidity and mortality. To date, limited data in subjects with impaired glucose tolerance and diabetes demonstrate nerve fiber repair after intervention. This may reflect a lack of efficacy of the interventions but may also reflect difficulty of the tests currently deployed to adequately assess nerve fiber repair, particularly in short-term studies. Corneal confocal microscopy (CCM) represents a novel noninvasive means to quantify nerve fiber damage and repair. Fifteen type 1 diabetic patients undergoing simultaneous pancreas-kidney transplantation (SPK) underwent detailed assessment of neurologic deficits, quantitative sensory testing (QST), electrophysiology, skin biopsy, corneal sensitivity, and CCM at baseline and at 6 and 12 months after successful SPK. At baseline, diabetic patients had a significant neuropathy compared with control subjects. After successful SPK there was no significant change in neurologic impairment, neurophysiology, QST, corneal sensitivity, and intraepidermal nerve fiber density (IENFD). However, CCM demonstrated significant improvements in corneal nerve fiber density, branch density, and length at 12 months. Normalization of glycemia after SPK shows no significant improvement in neuropathy assessed by the neurologic deficits, QST, electrophysiology, and IENFD. However, CCM shows a significant improvement in nerve morphology, providing a novel noninvasive means to establish early nerve repair that is missed by currently advocated assessment techniques. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| العلاقة: | https://eprints.qut.edu.au/219800/1/67418.pdfTest; Tavakoli, Mitra, Mitu-Pretorian, Maria, Petropoulos, Ioannis, Fadavi, Hassan, Asghar, Omar, Alam, Uazman, Ponirakis, Georgios, Jeziorska, Maria, Marshall, Andrew, Efron, Nathan, Boulton, Andrew, Augustine, Titus, & Malik, Rayaz (2013) Corneal confocal microscopy detects early nerve regeneration in diabetic neuropathy after simultaneous pancreas and kidney transplantation. Diabetes, 62(1), pp. 254-260.; https://eprints.qut.edu.au/219800Test/; Faculty of Health; Institute of Health and Biomedical Innovation |
| الإتاحة: | https://doi.org/10.2337/db12-0574Test https://eprints.qut.edu.au/219800Test/ |
| حقوق: | free_to_read ; http://creativecommons.org/licenses/by-nc-nd/2.5Test/ ; Consult author(s) regarding copyright matters ; This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au |
| رقم الانضمام: | edsbas.16215448 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |