دورية أكاديمية
Correlation between serum TNAP and myocardial fibrosis in patients after myocardial infarction
| العنوان: | Correlation between serum TNAP and myocardial fibrosis in patients after myocardial infarction |
|---|---|
| المؤلفون: | WANG Liyou, LEI Yunyi, GAO Lei, CHENG Xiaocheng, JIANG Dan |
| المصدر: | Di-san junyi daxue xuebao, Vol 42, Iss 11, Pp 1072-1077 (2020) |
| بيانات النشر: | Editorial Office of Journal of Third Military Medical University, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Medicine (General) |
| مصطلحات موضوعية: | tissue non-specific alkaline phosphatase, myocardial infarction, procollagen type ⅰ c-peptide, procollagen ⅲ n-terminal peptide, Medicine (General), R5-920 |
| الوصف: | Objective To investigate the relationship of tissue non-specific alkaline phosphatase (TNAP) with myocardial fibrosis in patients after myocardial infarction (MI). Methods Forty-six acute MI patients admitted to our hospital from March to November 2019 were enrolled in this study and assigned as the MI group, and another 41 patients with negative findings in coronary angiograms during the same period were collected as the control group. The serum TNAP activity was detected by alkaline phosphatase kit. The serum contents of procollagen type ⅠC-peptide (PⅠCP) and procollagen Ⅲ N-terminal peptide (PⅢNP) were detected by enzyme-linked immunosorbent assay (ELISA). Myocardial tissues from 5 patients who died of MI were collected. Collagen fiber area of heart was detected by Sirius red staining and the expression of TNAP was detected by immunohistochemistry. Ten 8-week-old male C57BL/6J mice were randomly divided into sham group and MI group (n=5). In 2 weeks after MI, all mice were sacrificed, and collagen fiber area of heart was detected by Masson staining and the expression of TNAP was detected by immunohistochemistry. Results Compared with the control group, the MI group had significantly increased serum TNAP activity (8.49±3.30 King U/100 mL, P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | Chinese |
| تدمد: | 1000-5404 45888221 |
| العلاقة: | http://aammt.tmmu.edu.cn/Upload/rhtml/201912297.htmTest; https://doaj.org/toc/1000-5404Test |
| DOI: | 10.16016/j.1000-5404.201912297 |
| الوصول الحر: | https://doaj.org/article/85538bb5862b45888221c4870619c5e8Test |
| رقم الانضمام: | edsdoj.85538bb5862b45888221c4870619c5e8 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 10005404 45888221 |
|---|---|
| DOI: | 10.16016/j.1000-5404.201912297 |