التفاصيل البيبلوغرافية
| العنوان: |
The influence of physical therapy and anti-botulinum toxin antibody on the efficacy of botulinum toxin-A injections in children with spastic cerebral palsy. |
| المؤلفون: |
Jang, Dae-Hyun, Sung, In Young |
| المصدر: |
Developmental Neurorehabilitation; Dec2014, Vol. 17 Issue 6, p414-419, 6p, 5 Charts |
| مصطلحات موضوعية: |
THERAPEUTICS, BOTULINUM toxin, CEREBRAL palsy, ENZYME-linked immunosorbent assay, INTRAMUSCULAR injections, RANGE of motion of joints, HEALTH outcome assessment, PHYSICAL therapy, RESEARCH funding, SPASTICITY, CALF muscles, TREATMENT effectiveness, PRE-tests & post-tests, DATA analysis software, DESCRIPTIVE statistics |
| مستخلص: |
Objective: To identify factors associated with the efficacy of botulinum toxin-A (BoNT-A) injections. Methods: Thirty-eight children with spastic cerebral palsy (CP) received BoNT-A injections into the gastrocnemius. The baseline anti-botulinum antibodies were checked. The Static dorsiflexion range of motion (ROM), Modified Tardieu Scale (MTS) and Physician Rating Scale (PRS) were assessed at pre-injection as well as 4- and 12-week post-injection. Results: No samples contained anti-botulinum antibodies. Greater baseline MTS dynamic range was associated with greater changes in MTS dynamic ranges at 4-week post-injection. More frequent physical therapy was associated with greater changes in static dorsiflexion ROM at 4-week post-injection and greater changes in PRS at 4- and 12-week post-injection. Conclusion: The improvement in PRS at 12-week post-injection was associated with the frequency of physical therapy. Therefore, intensive physical therapy programs may be necessary to maintain the beneficial effects of BoNT-A injections in children with CP. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
