The Working Memory Network and Its Association with Working Memory Performance in Survivors of non-CNS Childhood Cancer
| العنوان: | The Working Memory Network and Its Association with Working Memory Performance in Survivors of non-CNS Childhood Cancer |
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| المؤلفون: | Michael A. Grotzer, Nedelina Slavova, Manuela Pastore-Wapp, Valentin Benzing, Maja Steinlin, Valerie Siegwart, Leonie Steiner, Regula Everts, Kurt Leibundgut, Claudia M. Roebers, Mirko Schmidt, Claus Kiefer, Janine Sophie Spitzhüttl |
| المساهمون: | University of Zurich, Everts, Regula |
| المصدر: | Siegwart, Valerie; Steiner, Leonie; Pastore-Wapp, Manuela; Benzing, Valentin; Spitzhüttl, Janine; Schmidt, Mirko; Kiefer, Claus; Slavova, Nedelina; Grotzer, Michael; Roebers, Claudia; Steinlin, Maja; Leibundgut, Kurt; Everts, Regula (2021). The Working Memory Network and Its Association with Working Memory Performance in Survivors of non-CNS Childhood Cancer. Developmental neuropsychology, 46(3), pp. 249-264. Taylor & Francis 10.1080/87565641.2021.1922410 <http://dx.doi.org/10.1080/87565641.2021.1922410Test> |
| بيانات النشر: | Informa UK Limited, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, Childhood cancer, Central nervous system, 610 Medicine & health, 790 Sports, games & entertainment, Neuropsychological Tests, Audiology, 050105 experimental psychology, 3206 Neuropsychology and Physiological Psychology, 03 medical and health sciences, Cognition, 0302 clinical medicine, Neoplasms, Developmental and Educational Psychology, medicine, Humans, 0501 psychology and cognitive sciences, Survivors, Effects of sleep deprivation on cognitive performance, Child, Association (psychology), 3204 Developmental and Educational Psychology, medicine.diagnostic_test, Working memory, 05 social sciences, Parietal lobe, Magnetic Resonance Imaging, Memory, Short-Term, Neuropsychology and Physiological Psychology, medicine.anatomical_structure, 10036 Medical Clinic, 150 Psychology, Functional magnetic resonance imaging, Psychology, 030217 neurology & neurosurgery |
| الوصف: | Childhood cancer and its treatment puts survivors at risk of low working memory capacity. Working memory represents a core cognitive function, which is crucial in daily life and academic tasks. The aim of this functional MRI (fMRI) study was to examine the working memory network of survivors of childhood cancer without central nervous system (CNS) involvement and its relation to cognitive performance. Thirty survivors (aged 7-16 years, ≥ 1 year after cancer treatment) and 30 healthy controls performed a visuospatial working memory task during MRI, including a low- and a high-demand condition. Working memory performance was assessed using standardized tests outside the scanner. When cognitive demands increased, survivors performed worse than controls and showed evidence for slightly atypical working memory-related activation. The survivor group exhibited hyperactivation in the right-hemispheric superior parietal lobe (SPL) in the high- compared to the low-demand working memory condition, while maintaining their performance levels. Hyperactivation in the right SPL coincided with poorer working memory performance outside the scanner in survivors. Even in survivors of childhood cancer without CNS involvement, we find neural markers pointing toward late effects in the cerebral working memory network.AbbreviationsfMRI: Functional magnetic resonance imaging; CNS: Central nervous system; MNI: Montreal Neurological Institute; SES: Socioeconomic status; SPL: Superior parietal lobe. |
| وصف الملف: | 87565641.2021.pdf - application/pdf; application/pdf |
| تدمد: | 1532-6942 8756-5641 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b6d119282124a45daddb4451a2de64bTest https://doi.org/10.1080/87565641.2021.1922410Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9b6d119282124a45daddb4451a2de64b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15326942 87565641 |
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