Novel steroidogenic factor-1 homolog (ff1d) is coexpressed with anti-Mullerian hormone (AMH) in zebrafish
| العنوان: | Novel steroidogenic factor-1 homolog (ff1d) is coexpressed with anti-Mullerian hormone (AMH) in zebrafish |
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| المؤلفون: | Per-Erik Olsson, Anders Larsson, J. von Hofsten |
| المصدر: | Developmental Dynamics. 233:595-604 |
| بيانات النشر: | Wiley, 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | Anti-Mullerian Hormone, Male, Steroidogenic factor 1, endocrine system, Embryo, Nonmammalian, Molecular Sequence Data, Receptors, Cytoplasmic and Nuclear, Biology, Steroidogenic Factor 1, Testis, medicine, Animals, Humans, Amino Acid Sequence, Gene, Zebrafish, Phylogeny, Glycoproteins, Homeodomain Proteins, Genetics, Regulation of gene expression, urogenital system, Ovary, Gene Expression Regulation, Developmental, Anti-Müllerian hormone, DNA-binding domain, Zebrafish Proteins, Sertoli cell, biology.organism_classification, Cell biology, DNA-Binding Proteins, Testicular Hormones, Testis determining factor, medicine.anatomical_structure, biology.protein, Female, Sequence Alignment, Transcription Factors, Developmental Biology |
| الوصف: | ff1d is a novel zebrafish FTZ-F1 gene with sequence characteristics indicating similar basic regulatory mechanisms as the previously characterized ff1 based on the presence of an FTZ-F1 box in the DNA binding domain and an interactive domain (I-Box) and an AF-2 in the ligand binding domain. The highest sequence similarity was found between ff1d and ff1b (NR5A4), a gene previously shown to be a functional homolog to the steroidogenic factor 1 (SF-1). The expression pattern of ff1d was comparable to ff1b both in brain and gonads in adults and in the pituitary and interrenal cells in embryos. SF-1 is crucial in mammalian steroidogenesis and in sex determination by regulating the anti-Mullerian hormone (AMH). In fish, AMH has not been described previously. In this study, we cloned a partial zebrafish AMH. AMH was detected in growing oocytes, the ovarian follicular layer and testicular Sertoli cells, similar to the mammalian pattern, suggesting a conserved role between zebrafish and mammalian AMH. Teleosts lack a gene homolog to SRY, which constitute the universal testis-determining factor in mammalian sex determination. Comparison of sequences and expression patterns indicate that ff1d is a new candidate for sex determination and differentiation in a way similar to SF-1, possibly involving AMH. |
| تدمد: | 1097-0177 1058-8388 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04ccc344897a2efc84f47d1636c0006aTest https://doi.org/10.1002/dvdy.20335Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....04ccc344897a2efc84f47d1636c0006a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10970177 10588388 |
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