Arteries define the position of the thyroid gland during its developmental relocalisation
| العنوان: | Arteries define the position of the thyroid gland during its developmental relocalisation |
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| المؤلفون: | Osama A. Elsalini, Klaus B. Rohr, Georg C. Schwabe, Stefan Mundlos, Nele Haufs, Pamela Schrumpf, Burkhard Alt, Nathan D. Lawson, Annette Grüters, Heiko Krude |
| المصدر: | Development |
| بيانات النشر: | The Company of Biologists, 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | endocrine system, endocrine system diseases, Mesenchyme, Thyroid Gland, Morphogenesis, Embryonic Development, Mice, medicine.artery, medicine, Animals, Hedgehog Proteins, Aorta, Abdominal, Molecular Biology, Hedgehog, Zebrafish, Aorta, biology, Embryogenesis, Thyroid, Anatomy, biology.organism_classification, Phenotype, Mice, Mutant Strains, Carotid Arteries, medicine.anatomical_structure, Mutation, Endothelium, Vascular, Developmental Biology |
| الوصف: | During vertebrate development, the thyroid gland undergoes a unique relocalisation from its site of induction to a distant species-specific position in the cervical mesenchyme. We have analysed thyroid morphogenesis in wild-type and mutant zebrafish and mice, and find that localisation of growing thyroid tissue along the anteroposterior axis in zebrafish is linked to the development of the ventral aorta. In grafting experiments, ectopic vascular cells influence the localisation of thyroid tissue cell non-autonomously,showing that vessels provide guidance cues in zebrafish thyroid morphogenesis. In mouse thyroid development, the midline primordium bifurcates and two lobes relocalise cranially along the bilateral pair of carotid arteries. In hedgehog-deficient mice, thyroid tissue always develops along the ectopically and asymmetrically positioned carotid arteries, suggesting that, in mice (as in zebrafish), co-developing major arteries define the position of the thyroid. The similarity between zebrafish and mouse mutant phenotypes further indicates that thyroid relocalisation involves two morphogenetic phases, and that variation in the second phase accounts for species-specific differences in thyroid morphology. Moreover, the involvement of vessels in thyroid relocalisation sheds new light on the interpretation of congenital thyroid defects in humans. |
| وصف الملف: | application/pdf |
| تدمد: | 1477-9129 0950-1991 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::058a4cd5bcaacd9738266a304d4e4199Test https://doi.org/10.1242/dev.02550Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....058a4cd5bcaacd9738266a304d4e4199 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14779129 09501991 |
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