Mechanism of asymmetric ovarian development in chick embryos
| العنوان: | Mechanism of asymmetric ovarian development in chick embryos |
|---|---|
| المؤلفون: | Roshantha A.S. Chandraratna, Kiyotaka Toshimori, Hidefumi Yoshioka, Yuko Katoh-Fukui, Ken Ichirou Morohashi, Mamiko Maekawa, Yoshiyasu Ishimaru, Tomoko Komatsu, Hidesato Ogawa, Megumi Kasahara, Yoshiro Toyama |
| المصدر: | Development. 135:677-685 |
| بيانات النشر: | The Company of Biologists, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | endocrine system, medicine.medical_specialty, Gonad, medicine.drug_class, Tretinoin, Chick Embryo, Biology, Steroidogenic Factor 1, Models, Biological, Cyclin D1, Cytochrome P-450 Enzyme System, Downregulation and upregulation, Internal medicine, medicine, Animals, Primordium, Molecular Biology, Body Patterning, Cell Proliferation, Homeodomain Proteins, Regulation of gene expression, Ovary, Estrogen Receptor alpha, Gene Expression Regulation, Developmental, Retinoic Acid 4-Hydroxylase, Sex Determination Processes, Cell biology, medicine.anatomical_structure, Endocrinology, Nuclear receptor, Estrogen, Female, Estrogen receptor alpha, Signal Transduction, Transcription Factors, Developmental Biology |
| الوصف: | In most animals, the gonads develop symmetrically, but most birds develop only a left ovary. A possible role for estrogen in this asymmetric ovarian development has been proposed in the chick, but the mechanism underlying this process is largely unknown. Here, we identify the molecular mechanism responsible for this ovarian asymmetry. Asymmetric PITX2 expression in the left presumptive gonad leads to the asymmetric expression of the retinoic-acid (RA)-synthesizing enzyme, RALDH2, in the right presumptive gonad. Subsequently, RA suppresses expression of the nuclear receptors Ad4BP/SF-1 and estrogen receptor α in the right ovarian primordium. Ad4BP/SF-1 expressed in the left ovarian primordium asymmetrically upregulates cyclin D1 to stimulate cell proliferation. These data suggest that early asymmetric expression of PITX2 leads to asymmetric ovarian development through up- or downregulation of RALDH2,Ad4BP/SF-1, estrogen receptor α and cyclin D1. |
| تدمد: | 1477-9129 0950-1991 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4d82696d04169d53cdc0a88f78418c6Test https://doi.org/10.1242/dev.012856Test |
| رقم الانضمام: | edsair.doi.dedup.....d4d82696d04169d53cdc0a88f78418c6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14779129 09501991 |
|---|