Intern(euron)al affairs
| العنوان: | Intern(euron)al affairs |
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| المؤلفون: | Harald Hentschke, Christian Grasshoff, Luise Liebig |
| المصدر: | Der Anaesthesist. 65:609-614 |
| بيانات النشر: | Springer Science and Business Media LLC, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, Neocortex, Interneuron, business.industry, Central nervous system, General Medicine, Inhibitory postsynaptic potential, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Anesthesiology and Pain Medicine, medicine.anatomical_structure, GABA Agents, medicine, Biological neural network, GABAergic, business, Neuroscience, 030217 neurology & neurosurgery, Acetylcholine, medicine.drug |
| الوصف: | Acetylcholine is a neuromodulator which is released throughout the central nervous system and plays an essential role in consciousness and cognitive processes including attention and learning. Due to its 'activating' effect on the neuronal and behavioral level its interaction with anesthetics has long been of interest to anesthesiologists. It is widely held that a reduction of the release of acetylcholine by general anesthetics constitutes part of the anesthetic effect. This notion is backed by numerous human and animal studies, but is also in seeming contradiction to findings that acetylcholine activates specific classes of inhibitory neurons: if acetylcholine excites elements within the neuronal network responsible for the release of the inhibitory neurotransmitter γ-aminobutyric acid (GABA), its withdrawal should diminish, not enhance, the effect of anesthetics.Focusing on cortical circuits, we present an overview of recent advances in cellular neurophysiology, particularly the interactions between inhibitory neuron classes, which provide insights on the interaction between acetylcholine and GABA. |
| تدمد: | 1432-055X 0003-2417 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::bb62633365ba72b4d0eabb7462517a65Test https://doi.org/10.1007/s00101-016-0197-9Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi...........bb62633365ba72b4d0eabb7462517a65 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1432055X 00032417 |
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