Interpersonal life stress, inflammation, and depression in adolescence
| العنوان: | Interpersonal life stress, inflammation, and depression in adolescence |
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| المؤلفون: | Matteo Giletta, Sarah W. Helms, George M. Slavich, Paul D. Hastings, Matthew K. Nock, Karen D. Rudolph, Mitchell J. Prinstein |
| المساهمون: | Developmental Psychology |
| المصدر: | Depress Anxiety Depression and anxiety, vol 37, iss 2 Depression and Anxiety, 37(2), 179-193. Wiley-Blackwell |
| بيانات النشر: | Wiley-Blackwell, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, vulnerability, Interleukin-1beta, Poison control, Disease, Interleukin-1beta/analysis, Tumor Necrosis Factor-alpha/analysis, 0302 clinical medicine, Models, Medicine, Psychology, Aetiology, Child, Depression (differential diagnoses), risk, Pediatric, Psychiatry, Psychopathology, Depression, social stress, Serious Mental Illness, Inflammation/complications, Psychiatry and Mental health, Clinical Psychology, Mental Health, Depression/complications, Major depressive disorder, Female, social and economic factors, Clinical psychology, Adolescent, Clinical Sciences, Models, Psychological, Stress, Article, Interviews as Topic, 03 medical and health sciences, Interpersonal relationship, Saliva/immunology, Clinical Research, 2.3 Psychological, Behavioral and Social Science, Humans, Interpersonal Relations, Saliva, development, Psychological/complications, Social stress, Stress, Psychological/complications, Inflammation, disease, major depressive disorder, business.industry, Tumor Necrosis Factor-alpha, Prevention, Inflammatory and immune system, Stressor, medicine.disease, cytokines, 030227 psychiatry, Brain Disorders, Good Health and Well Being, Psychological, business, Mind and Body, 030217 neurology & neurosurgery, Stress, Psychological |
| الوصف: | Background Depression rates increase markedly for girls across the adolescent transition, but the social-environmental and biological processes underlying this phenomenon remain unclear. To address this issue, we tested a key hypothesis from Social Signal Transduction Theory of Depression, which posits that individuals who mount stronger inflammatory responses to social stress should exhibit greater increases in depressive symptoms following interpersonal life stress exposure than those who mount weaker inflammatory responses to such stress. Method Participants were 116 adolescent girls (M-age = 14.71) at risk for psychopathology, defined as having a history of mental health concerns (e.g., psychiatric treatment, significant symptoms) over the past 2 years. At baseline, we characterized their inflammatory reactivity to social stress by quantifying their salivary proinflammatory cytokine responses to a laboratory-based social stressor. Then, 9 months later, we assessed the interpersonal and noninterpersonal stressful life events that they experienced over the prior 9 months using an interview-based measure of life stress. Results As hypothesized, greater interpersonal life stress exposure was associated with significant increases in depression over time, but only for girls exhibiting stronger salivary tumor necrosis factor-alpha and interleukin-1 beta reactivity to social stress. In contrast, noninterpersonal stress exposure was unrelated to changes in depression longitudinally, both alone and when combined with youths' cytokine reactivity scores. Discussion These results are consistent with Social Signal Transduction Theory of Depression and suggest that heightened inflammatory reactivity to social stress may increase adolescents' risk for depression. Consequently, it may be possible to reduce depression risk by modifying inflammatory responses to social stress. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1520-6394 1091-4269 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::579f02b5a0f18e39417decfd8f9c4228Test https://research.tilburguniversity.edu/en/publications/4c424d52-8982-4610-a1f2-c60766fa535dTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....579f02b5a0f18e39417decfd8f9c4228 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15206394 10914269 |
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