دورية أكاديمية
Predictive value of cytokine gene polymorphisms for the development of end-stage renal disease.
| العنوان: | Predictive value of cytokine gene polymorphisms for the development of end-stage renal disease. |
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| المؤلفون: | Babel, Nina, Gabdrakhmanova, Lelia, Hammer, Markus H, Schoenemann, Constanze, Skrypnikov, Volodimir, Poliak, Nina, Volk, Hans-Dieter, Reinke, Petra |
| المصدر: | Department of Pediatrics |
| بيانات النشر: | LVHN Scholarly Works |
| سنة النشر: | 2006 |
| المجموعة: | Lehigh Valley Health Network: LVHN Scholarly Works |
| مصطلحات موضوعية: | Adult, Aged, Cytokines, Diabetic Nephropathies, Female, Germany, Glomerulonephritis, Humans, Kidney Failure, Chronic, Male, Middle Aged, Polymorphism, Single Nucleotide, Department of Pediatrics, Medicine and Health Sciences, Pediatrics |
| الوصف: | BACKGROUND: Cytokines play a crucial role in different immunopathological conditions. Cytokine secretion is reported to be determined by polymorphisms in the cytokine genes. Since TNF-alfa and IL-10 are involved in regulation of inflammation, and TGF-beta 1 can induce fibrosis and renal insufficiency - dominant features of end-stage renal disease (ESRD), we explored the hypothesis that polymorphisms of these cytokine genes may be possible genetic susceptibility factors for the progression of renal failure. METHODS: We studied the IL-10 (-1082), TNF-alfa (-308), TGF-beta 1 (codon 10;25) gene single nucleotide polymorphisms in 118 healthy donors and 103 patients with ESRD (44 hemodialysis patients with diabetic nephropathy and 59 hemodialysis patients with glomerulonephritis) using PCR-SSP. RESULTS: Significant associations of ESRD with the TGF-beta 1 (codon 10) TT (odds ratio [OR] = 5.31; 95% confidence interval [95% CI], 3.77-7.02; p CONCLUSIONS: Carriage of the TGF-beta 1 (codon 10) TT and IL-10 (-1082) GG genotypes may increase susceptibility to ESRD in German patients with type 2 diabetes or glomerulonephritis. |
| نوع الوثيقة: | text |
| اللغة: | unknown |
| العلاقة: | https://scholarlyworks.lvhn.org/pediatrics/1126Test; https://pubmed.ncbi.nlm.nih.gov/17173255Test/ |
| الإتاحة: | https://scholarlyworks.lvhn.org/pediatrics/1126Test https://pubmed.ncbi.nlm.nih.gov/17173255Test/ |
| رقم الانضمام: | edsbas.6702CA11 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |