دورية أكاديمية
Letter: Thrombotic Neurovascular Disease in COVID-19 Patients.
| العنوان: | Letter: Thrombotic Neurovascular Disease in COVID-19 Patients. |
|---|---|
| المؤلفون: | Sweid, Ahmad, Hammoud, Batoul, Weinberg, Joshua H., Oneissi, Mazen, Raz, Eytan, Shapiro, Maksim, DePrince, Maureen, Tjoumakaris, Stavropoula, Gooch, Michael R., Herial, Nabeel A., Zarzour, Hekmat, Romo, Victor, Rosenwasswer, Robert, Jabbour, Pascal |
| المصدر: | Department of Neurosurgery Faculty Papers |
| بيانات النشر: | Jefferson Digital Commons |
| سنة النشر: | 2020 |
| المجموعة: | Jefferson Digital Commons (Thomas Jefferson University, Philadelphia) |
| مصطلحات موضوعية: | COVID-19, SARS-CoV-2, coronavirus, Medicine and Health Sciences, Neurology, Surgery |
| الوصف: | Although the respiratory system is the primary target of the coronavirus, studies have demonstrated a strong tropism to the central nervous system (CNS).1,2 The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects cells by binding to the angiotensin-converting enzyme 2 (ACE2) receptor. This receptor is also found in the CNS and plays a crucial role in autoregulating cerebral perfusion pressure.3,4 Additionally, epidemiological data demonstrated increased mortality due to cardiovascular and cerebrovascular diseases during flu pandemics due to a hypercoagulable state.5,6 The triad of neuroinvasion of SARS-CoV-2, induction of hypercoagulable state,5-9 and the inhibition of ACE2 blocking the formation of Angiotensin (1-7) serve as the pathophysiology for neurovascular insults.3,4 We present a case series of coronavirus disease 2019 (COVID-19) patients from 2 health systems developing cerebrovascular insult. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://jdc.jefferson.edu/neurosurgeryfp/126Test; https://jdc.jefferson.edu/cgi/viewcontent.cgi?article=1128&context=neurosurgeryfpTest |
| الإتاحة: | https://jdc.jefferson.edu/neurosurgeryfp/126Test https://jdc.jefferson.edu/cgi/viewcontent.cgi?article=1128&context=neurosurgeryfpTest |
| رقم الانضمام: | edsbas.D30488FB |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |