دورية أكاديمية
Pulmonary hypertension in sickle cell disease.
| العنوان: | Pulmonary hypertension in sickle cell disease. |
|---|---|
| المؤلفون: | Ataga, Kenneth I, Sood, Namita, De Gent, Guy, Kelly, Eileen, Henderson, Ashley G, Jones, Susan, Strayhorn, Dell, Lail, Alice, Lieff, Susan, Orringer, Eugene P |
| المصدر: | Department of Medicine |
| بيانات النشر: | LVHN Scholarly Works |
| سنة النشر: | 2004 |
| المجموعة: | Lehigh Valley Health Network: LVHN Scholarly Works |
| مصطلحات موضوعية: | Adult, Anemia, Sickle Cell, Cross-Sectional Studies, Echocardiography, Doppler, Female, Hematologic Tests, Humans, Hypertension, Pulmonary, Logistic Models, Male, Prevalence, Respiratory Function Tests, Department of Medicine, Medicine and Health Sciences |
| الوصف: | BACKGROUND: Recurrent vaso-occlusive episodes lead to progressive end-organ damage in patients with sickle cell disease. We sought to determine the prevalence of pulmonary hypertension in adult patients with sickle cell disease and to identify factors associated with this life-threatening complication. METHODS: Sixty patients (> or =18 years of age; mean [+/- SD] age, 37 +/- 13 years) followed at a University Medical Center were evaluated. They were selected by a systematic sampling of patients presenting to the clinic for routine follow-up visits. All enrolled subjects underwent a clinical examination, Doppler echocardiography, pulmonary function tests, and hematologic tests during a single visit. Pulmonary hypertension was defined using an age- and body mass index-adjusted nomogram. RESULTS: The prevalence of pulmonary hypertension was 30% (18/60). Ten patients had mild pulmonary hypertension (up to 44 mm Hg), 5 had moderate pulmonary hypertension (45 to 74 mm Hg), and 2 had severe pulmonary hypertension (> or =75 mm Hg). In a logistic regression model, both lower fetal hemoglobin level and lower systolic blood pressure were associated with the presence of pulmonary hypertension. CONCLUSION: We found that the prevalence of pulmonary hypertension in adult patients with sickle cell disease was substantial, particularly in those with lower levels of fetal hemoglobin and lower systolic blood pressure. |
| نوع الوثيقة: | text |
| اللغة: | unknown |
| العلاقة: | https://scholarlyworks.lvhn.org/medicine/4622Test; https://pubmed.ncbi.nlm.nih.gov/15501204Test/ |
| الإتاحة: | https://scholarlyworks.lvhn.org/medicine/4622Test https://pubmed.ncbi.nlm.nih.gov/15501204Test/ |
| رقم الانضمام: | edsbas.1987FDE6 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |