دورية أكاديمية
Evaluation of IL-8 gene polymorphisms in patients with periodontitis in Hamedan, Iran
| العنوان: | Evaluation of IL-8 gene polymorphisms in patients with periodontitis in Hamedan, Iran |
|---|---|
| المؤلفون: | Behzad Houshmand, Mehrdad Hajilooi, Alireza Rafiei, Mohsen Bidgoli, Sara Soheilifar |
| المصدر: | Dental Research Journal, Vol 9, Iss 4, Pp 427-432 (2012) |
| بيانات النشر: | Wolters Kluwer Medknow Publications, 2012. |
| سنة النشر: | 2012 |
| المجموعة: | LCC:Dentistry |
| مصطلحات موضوعية: | Aggressive periodontitis, chronic periodontitis, genetic polymorphism, interleukin-8, Dentistry, RK1-715 |
| الوصف: | Background: Many environmental and genetic factors are known as factors that increase the susceptibility to periodontitis. As IL-8 is a chemokine that mediate the inflammatory process in periodontal disease, we decided to evaluate the effect of its polymorphism on chronic and aggressive periodontitis. Materials and Methods: In this cross-sectional study DNA was isolated from the whole blood of 107 periodontitis patients and 199 healthy individuals. All samples were genotyped for the IL-8 polymorphisms using the polymerase chain reaction with sequence specific primers. The distribution of the interleukin-8 genotype and allele frequencies in control and disease groups was analyzed by the Chi-square test and a P-value of < 0.05 was considered statistically significant. Results: The findings revealed that the allele and genotype frequencies of A2767T, T 1 1722T 2 , and C781T polymorphism of IL-8 gene were not significantly differed between controls and patients. However, there was a significant difference in the genotype frequencies of IL-8 A251T (P < 0.0001), G396T (P < 0.0001), and C1633T (P < 0.0001) gene polymorphism between the patient and the control groups. Additionally, there was a significant difference in the genotype frequencies of C1633T (P < 0.05) polymorphism of IL-8 gene between the aggressive and chronic periodontitis. Conclusion: IL-8 gene polymorphism may be protective against periodontitis. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1735-3327 2008-0255 |
| العلاقة: | http://www.drjjournal.net/article.asp?issn=1735-3327;year=2012;volume=9;issue=4;spage=427;epage=432;aulast=HoushmandTest; https://doaj.org/toc/1735-3327Test; https://doaj.org/toc/2008-0255Test |
| DOI: | 10.4103/1735-3327.102778 |
| الوصول الحر: | https://doaj.org/article/2ec7949f2dbf4b64822bb654371a9db7Test |
| رقم الانضمام: | edsdoj.2ec7949f2dbf4b64822bb654371a9db7 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 17353327 20080255 |
|---|---|
| DOI: | 10.4103/1735-3327.102778 |