MiR-548c-3p inhibits the proliferation, migration and invasion of human breast cancer cell by targeting E2F3
| العنوان: | MiR-548c-3p inhibits the proliferation, migration and invasion of human breast cancer cell by targeting E2F3 |
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| المؤلفون: | Pei-Yi Tan, Hua-Nan Li, Shi-Wei Chai, Liu-Jing Wen |
| المصدر: | Cytotechnology |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Cell growth, business.industry, Clinical Biochemistry, Biomedical Engineering, Bioengineering, Cell Biology, medicine.disease, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Breast cancer, Apoptosis, 030220 oncology & carcinogenesis, Cancer cell, Cancer research, Medicine, Original Article, Breast cancer cells, skin and connective tissue diseases, business, Normal control, Human breast, Biotechnology, E2F2 |
| الوصف: | MiR-548 has been reported to be involved in a variety of tumor processes, but its function in breast cancer remains unclear. In this study, we found that miR-548 was low expressed in breast cancer tissues and cells compared with normal control. We then examined whether up-regulation of miR-548 could improve the progression of breast cancer. Our results indicate that up-regulation of miR-548 significantly inhibits cell proliferation, migration andinvasion, and induces apoptosis in breast cancer cells. Further studies showed that miR-548 could specifically inhibit E2F3 expression. Moreover, rescue test showed that up-regulation of E2F2 could reverse the effect of miR-548 on proliferation, migration, invasion and apoptosis of breast cancer cells. In general, miR-548 could improve the progression of breast cancer. By targeting E2F2, which may make a potential target for the treatment of breast cancer. |
| تدمد: | 1573-0778 0920-9069 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42181a62ee344bbe125e8cfa756c8215Test https://doi.org/10.1007/s10616-020-00418-3Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....42181a62ee344bbe125e8cfa756c8215 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15730778 09209069 |
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