The enigmatic role of IL-38 in inflammatory diseases
| العنوان: | The enigmatic role of IL-38 in inflammatory diseases |
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| المؤلفون: | Mathilde Harel, T Garraud, Marie-Astrid Boutet, Frédéric Blanchard, Benoit Le Goff |
| المساهمون: | maurice, sandrine, Sarcomes osseux et remodelage des tissus calcifiés - Phy-Os [Nantes - INSERM U1238] (Phy-Os), Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Bretagne Loire (UBL)-Centre hospitalier universitaire de Nantes (CHU Nantes), Département de Rhumatologie (Rhumato - HD - NANTES), Hôtel-Dieu de Nantes, Physiopathologie des Adaptations Nutritionnelles (PhAN), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), This work was supported by Inserm, the Arthritis Foundation, the French Society of Rheumatology, Pfizer and the Région Pays de la Loire (Bioregate)., Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Bretagne Loire (UBL)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN) |
| المصدر: | Cytokine and Growth Factor Reviews Cytokine and Growth Factor Reviews, Elsevier, 2018, Epub ahead of print. ⟨10.1016/j.cytogfr.2018.01.001⟩ |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Immunology, Arthritis, Inflammation, Context (language use), General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Psoriatic arthritis, Mice, Psoriasis, medicine, Immunology and Allergy, Animals, Humans, Spondylitis, Ankylosing, Receptors, Cytokine, Receptor, IL-1F, Ankylosing spondylitis, [SDV.MHEP.RSOA] Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, business.industry, Interleukins, Arthritis, Psoriatic, Toll-Like Receptors, Receptors, Interleukin-1, Cell Differentiation, Receptors, Interleukin, medicine.disease, 3. Good health, IL-38, 030104 developmental biology, Cytokine, [SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, Th17 Cells, medicine.symptom, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Interleukin-1 |
| الوصف: | International audience; IL-38 is the most recently discovered cytokine of the IL-1 family and is considered a potential inhibitor of the IL-1 and Toll-like receptor families. IL-38 exerts anti-inflammatory properties, especially on macrophages, by inhibiting secretion of pro-inflammatory cytokines, leading to reduced T-lymphocyte TH17 maturation. IL-38 has been studied most extensively in the context of chronic inflammatory diseases, particularly arthritis, where it is considered an attractive new drug candidate. IL-38 research has entered a new phase, with the realization that IL-38 is important in the pathophysiology of TH17 dependent-diseases (psoriasis, psoriatic arthritis and anky-losing spondylitis). In this review, we provide a critical evaluation of several controversial issues concerning IL-38 function and regulation. There is effectively contrasting data regarding IL-38: it is produced in conditions such as apoptosis, necrosis or inflammation, but data is lacking regarding IL-38 processing and biological function. Furthermore, the receptor for IL-38 has yet to be identified, although three candidate receptors – IL-1R1, IL-36R and IL-1RAPL1–have been proposed. Future studies will hopefully uncover new aspects of this enigmatic cytokine. |
| وصف الملف: | application/pdf |
| تدمد: | 1879-0305 1359-6101 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b09a0c671ed6511ccdd51fdadc9827d0Test https://pubmed.ncbi.nlm.nih.gov/29366546Test |
| حقوق: | EMBARGO |
| رقم الانضمام: | edsair.doi.dedup.....b09a0c671ed6511ccdd51fdadc9827d0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18790305 13596101 |
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