التفاصيل البيبلوغرافية
| العنوان: |
Myeloid-derived growth factor and its effects on cardiovascular and metabolic diseases. |
| المؤلفون: |
Xu, Jinling1 (AUTHOR), Song, Yanzhuo1,2 (AUTHOR), Ding, Sheng1 (AUTHOR), Duan, Weizhe1 (AUTHOR), Xiang, Guangda1,3 (AUTHOR) Guangda64@hotmail.com, Wang, Zhongjing1 (AUTHOR) doctorwangzj@163.com |
| المصدر: |
Cytokine & Growth Factor Reviews. Apr2024, Vol. 76, p77-85. 9p. |
| مصطلحات موضوعية: |
*HEART, *CARDIAC regeneration, *CARDIOVASCULAR diseases, *METABOLIC disorders, *NON-alcoholic fatty liver disease, *CARDIOVASCULAR system, *TYPE 2 diabetes |
| مستخلص: |
Myeloid-derived growth factor (MYDGF) is a paracrine protein produced by bone marrow-derived monocytes and macrophages. Current research shows that it has protective effects on the cardiovascular system, such as repairing heart tissue after myocardial infarction, enhancing cardiomyocyte proliferation, improving cardiac regeneration after myocardial injury, regulating proliferation and survival of endothelial cells, reducing endothelial cell damage, resisting pressure overload-induced heart failure, as well as protecting against atherosclerosis. Furthermore, regarding the metabolic diseases, MYDGF has effects of improving type 2 diabetes mellitus, relieving non-alcoholic fatty liver disease, alleviating glomerular diseases, and resisting osteoporosis. Herein, we will discuss the biology of MYDGF and its effects on cardiovascular and metabolic diseases. [Display omitted] • MYDGF is a paracrine protein produced by bone marrow-derived monocytes and macrophages. • MYDGF is an endoplasmic reticulum-resident protein. • MYDGF has great potential as a biomarker for CVMD diagnosis and prognosis. • MYDGF is a potential therapeutic target for CVMD. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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