التفاصيل البيبلوغرافية
| العنوان: |
The determinant role of IL-6 in the establishment of inflammation leading to spontaneous preterm birth. |
| المؤلفون: |
Prairie, Elizabeth1,2 (AUTHOR), Côté, France1,2 (AUTHOR), Tsakpinoglou, Marika2 (AUTHOR), Mina, Michael2 (AUTHOR), Quiniou, Christiane1 (AUTHOR) cquiniou@gmail.com, Leimert, Kelycia3 (AUTHOR), Olson, David3 (AUTHOR), Chemtob, Sylvain1,2 (AUTHOR) sylvain.chemtob@umontreal.ca |
| المصدر: |
Cytokine & Growth Factor Reviews. Jun2021, Vol. 59, p118-130. 13p. |
| مصطلحات موضوعية: |
*PREMATURE labor, *INTERLEUKIN-6, *CHILDBIRTH, *INFLAMMATORY mediators, *FETAL tissues, *PUBLIC health, *MATERNALLY acquired immunity |
| مستخلص: |
[Display omitted] • Il-6 enables the production of sustained and sufficient inflammation during preterm birth. • IL-6 and initiates an immune response mediated by neutrophil, macrophages and lymphocytes cells during preterm birth. • Recruitment and activation of immune cells by IL-6 secretion can be observed both at the fetal and maternal level, creating a hostile environment. • This review addresses the importance and development of new therapies to alleviate this urgent and unmet medical need. Preterm birth (PTB) and its consequences are a major public health concern as preterm delivery is the main cause of mortality and morbidity at birth. There are many causes of PTB, but inflammation is undeniably associated with the process of premature childbirth and fetal injury. At present, treatments clinically available mostly involve attempt to arrest contractions (tocolytics) but do not directly address upstream maternal inflammation on development of the fetus. One of the possible solutions may lie in the modulation of inflammatory mediators. Of the many pro-inflammatory cytokines involved in the induction of PTB, IL-6 stands out for its pleiotropic effects and its involvement in both acute and chronic inflammation. Here, we provide a detailed review of the effects of IL-6 on the timing of childbirth, its occurrence during PTB and its indissociable roles with associated fetal tissue damage. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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