Isolation and comparative mapping of a human chromosome 20-specific α-satellite DNA clone
| العنوان: | Isolation and comparative mapping of a human chromosome 20-specific α-satellite DNA clone |
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| المؤلفون: | Mariano Rocchi, Viji Shridhar, Dorothy A. Miller, R. Carbone, David C. Ward, Antonio Baldini, Orlando J. Miller, A. Bolino, Nicoletta Archidiacono |
| المصدر: | Cytogenetic and Genome Research. 59:12-16 |
| بيانات النشر: | S. Karger AG, 1992. |
| سنة النشر: | 1992 |
| مصطلحات موضوعية: | Pan troglodytes, Chromosomes, Human, Pair 20, Locus (genetics), P1-derived artificial chromosome, DNA, Satellite, Biology, Fluorescence, Gene mapping, Chromosome 19, Genetics, medicine, Animals, Humans, Molecular Biology, Genetics (clinical), Gorilla gorilla, medicine.diagnostic_test, Chromosome Mapping, Nucleic Acid Hybridization, Chromosome, Blotting, Southern, Chromosomes, Human, Pair 2, Chromosome 20, Chromosome 22, Fluorescence in situ hybridization |
| الوصف: | We have isolated and characterized a human genomic DNA clone (PZ20, locus D20Z2) that identifies, under high-stringency hybridization conditions, an alphoid DNA subset specific for chromosome 20. The specificity was determined using fluorescence in situ hybridization. Sequence analysis confirmed our previously reported data on the great similarity between the chromosome 20 and chromosome 2 alphoid subsets. Comparative mapping of pZ20 on chimpanzee and gorilla chromosomes, also performed under high-stringency conditions, indicates that the alphoid subset has ancestral sequences on chimpanzee chromosome 11 and gorilla chromosome 19. However, no hybridization was observed to chromosomes 21 in the great apes, the homolog of human chromosome 20. |
| تدمد: | 1424-859X 1424-8581 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::939a30ff36bae3f5fb7f1fce93d9613cTest https://doi.org/10.1159/000133188Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....939a30ff36bae3f5fb7f1fce93d9613c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1424859X 14248581 |
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