التفاصيل البيبلوغرافية
| العنوان: |
Coptisine Reduces the Progression of Cervical Cancer Through Induction of Autophagy. |
| المؤلفون: |
Yaping Zhao1, Xia Gao2 gx_gaoxia0805@163.com |
| المصدر: |
Current Topics in Nutraceutical Research. Feb2023, Vol. 21 Issue 1, p18-24. 7p. |
| مصطلحات موضوعية: |
*PROTEINS, *STATISTICS, *AUTOPHAGY, *COLONY-forming units assay, *WESTERN immunoblotting, *PHOSPHOTRANSFERASES, *ONE-way analysis of variance, *ISOQUINOLINE, *APOPTOSIS, *B cell lymphoma, *MTOR inhibitors, *HEALTH outcome assessment, *CELL survival, *CELLULAR signal transduction, *T-test (Statistics), *CELL proliferation, *DESCRIPTIVE statistics, *CELL lines, *MOLECULAR structure, *DATA analysis software, *DATA analysis, *PHARMACODYNAMICS, CERVIX uteri tumors |
| مستخلص: |
The regulatory role of coptisine on autophagy in cervical cancer cells (in HcerEpic, HeLa, and SiHa) was examined by assessment of cell viability, colony formation, and apoptosis. Coptisine, in a dose-dependent fashion, significantly inhibited cervical cancer cell viability as measured by cell proliferation, transwell, and TUNEL assays. Coptisine inhibited the levels of p62 and Bcl-2, whilst it promoted the accumulation of Atg5, LC3II/LC3I and Bax. These data taken together suggest that coptisine inhibits the progression of cervical cancer cells by enhancing autophagy through suppression of the PI3K/AKT/ mTOR pathway. This represents a theoretical foundation for developing novel cervical cancer treatments. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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