Cognitive interventions in Alzheimer's and Parkinson's diseases: emerging mechanisms and role of imaging
| العنوان: | Cognitive interventions in Alzheimer's and Parkinson's diseases: emerging mechanisms and role of imaging |
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| المؤلفون: | Julie A. Fields, Prashanthi D Vemuri, Jessica Peter, Stefan Klöppel |
| المصدر: | Current Opinion in Neurology |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Psychotherapist, Parkinson's disease, medicine.medical_treatment, neuroplasticity, Psychological intervention, Disease, 050105 experimental psychology, Scientific evidence, cognitive training, Mice, 03 medical and health sciences, Cognition, 0302 clinical medicine, Alzheimer Disease, medicine, Animals, Humans, 0501 psychology and cognitive sciences, Cognitive Behavioral Therapy, 05 social sciences, imaging, Brain, Parkinson Disease, Alzheimer's disease, medicine.disease, Cognitive Remediation, Cognitive training, Cognitive behavioral therapy, Neurology, Cognitive remediation therapy, NEUROIMAGING: Edited by Stefan Klöppel, Neurology (clinical), Psychology, Biomarkers, 030217 neurology & neurosurgery, Clinical psychology |
| الوصف: | Purpose of review There has been recent debate about the lack of compelling scientific evidence on the efficacy of cognitive interventions. The goal of this study is to review the current state of cognitive interventions in Alzheimer's disease and Parkinson's disease, present emerging mechanisms, and discuss the role of imaging in designing effective intervention strategies. Recent findings Cognitive interventions appear to be promising in Alzheimer's disease and Parkinson's disease. Although feasibility has been shown in mild cognitive impairment, early Alzheimer's disease, and mild to moderate Parkinson's disease, studies to investigate long-term efficacy and mechanisms underlying these interventions are still needed. Summary There is a need to conduct scientifically rigorous studies to validate the efficacy of cognitive intervention trials. Future studies will greatly benefit from including longitudinal imaging in their study design. Imaging can be used to demonstrate the efficacy and mechanisms by measuring brain changes over the intervention period. Imaging can also be used to determine biological and disease-related factors that may influence the treatment response, that is, the effect modifiers. Consideration of effect modifiers will allow us to measure the treatment response in biomarkers and cognition with greater sensitivity and also aid in designing trials that will lead to better patient outcomes. |
| تدمد: | 1473-6551 1350-7540 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9b82e324a9e5b3a62bf8c49ac59960eTest https://doi.org/10.1097/wco.0000000000000346Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e9b82e324a9e5b3a62bf8c49ac59960e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14736551 13507540 |
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