Antiatherogenic function of HDL particle subpopulations: focus on antioxidative activities
| العنوان: | Antiatherogenic function of HDL particle subpopulations: focus on antioxidative activities |
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| المؤلفون: | Anatol Kontush, M. John Chapman |
| المساهمون: | Dyslipidémies, inflammation et athérosclérose dans les maladies métaboliques, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Chapman, John, Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP) |
| المصدر: | Current Opinion in Lipidology Current Opinion in Lipidology, Lippincott, Williams & Wilkins, 2010, 21 (4), pp.312-8. ⟨10.1097/MOL.0b013e32833bcdc1⟩ Current Opinion in Lipidology, 2010, 21 (4), pp.312-8. ⟨10.1097/MOL.0b013e32833bcdc1⟩ |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Apolipoprotein B, Endocrinology, Diabetes and Metabolism, PAF-AH, 030204 cardiovascular system & hematology, medicine.disease_cause, MESH: Lipoproteins, HDL, Antioxidants, MESH: Atherosclerosis, lipid hydroperoxides, chemistry.chemical_compound, 0302 clinical medicine, High-density lipoprotein, oxidative stress, MESH: Animals, 0303 health sciences, MESH: Oxidative Stress, Nutrition and Dietetics, biology, Lipidome, PON1, [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, 3. Good health, rigidity, Biochemistry, Low-density lipoprotein, oxidized phospholipids, lipids (amino acids, peptides, and proteins), Lipoproteins, HDL, Cardiology and Cardiovascular Medicine, medicine.medical_specialty, LCAT, apolipoprotein A-I, fluidity, Proinflammatory cytokine, 03 medical and health sciences, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Internal medicine, Genetics, medicine, Animals, Humans, Molecular Biology, 030304 developmental biology, MESH: Humans, MESH: Antioxidants, nutritional and metabolic diseases, Cell Biology, Atherosclerosis, Endocrinology, chemistry, oxidized LDL, biology.protein, Oxidative stress, Lipoprotein |
| الوصف: | International audience; Oxidative stress, an emerging risk factor for premature atherosclerosis and cardiovascular disease, mediates the formation of proinflammatory, pro-atherogenic oxidized low-density lipoprotein (oxLDL) in the arterial intima. Circulating HDL particles, and particularly small, dense, protein-rich HDL3, may provide potent protection of LDL in vivo from oxidative damage by free radicals in the arterial intima, resulting in the inhibition of the generation of proinflammatory oxidized lipids, primarily lipid hydroperoxides (LOOH) but also short-chain oxidized phospholipids (oxPL). HDL-mediated inactivation of LOOH involves initial transfer of phospholipid hydroperoxides (PLOOH) from LDL to HDL3, which is governed by the rigidity of the surface monolayer of HDL, and subsequent reduction of PLOOH by redox-active Met residues of apolipoprotein A-I (apoA-I) with the formation of phospholipid hydroxides (PLOH) and methionine sulphoxides. HDL-associated enzymes may in turn contribute to the hydrolytic inactivation of short-chain oxPL. Mounting evidence suggests that the integrated antioxidative activity of HDL appear to be defective in atherogenic dyslipidaemias involving low HDL-cholesterol levels; anomalies in the proteome and lipidome of HDL particles in dyslipidaemic patients may underlie such functional deficiency. Pharmacological normalization of HDL metabolism concomitantly with correction of circulating levels, composition and biological activities of HDL particles, with enrichment in apoA-I and reduction in HDL surface rigidity, may constitute an efficacious therapeutic approach to attenuate atherosclerosis in dyslipidaemic patients at high cardiovascular risk. |
| وصف الملف: | application/pdf |
| تدمد: | 0957-9672 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61e6ddc84c899f1470ae7e9a853e2056Test https://doi.org/10.1097/mol.0b013e32833bcdc1Test |
| حقوق: | EMBARGO |
| رقم الانضمام: | edsair.doi.dedup.....61e6ddc84c899f1470ae7e9a853e2056 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 09579672 |
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