التفاصيل البيبلوغرافية
| العنوان: |
Sulfotransferases, sulfatases and formylglycine-generating enzymes: a sulfation fascination |
| المؤلفون: |
Bojarová, Pavla, Williams, Spencer J1 sjwill@unimelb.edu.au |
| المصدر: |
Current Opinion in Chemical Biology. Oct2008, Vol. 12 Issue 5, p573-581. 9p. |
| مصطلحات موضوعية: |
*SULFOTRANSFERASES, *SULFATASES, *GLYCINE, *CATALYSIS, *ENZYMES, *STRUCTURAL analysis (Science) |
| مستخلص: |
Sulfotransferases and sulfatases are the major enzymes responsible for sulfate transfer processes. The past two years have seen the elucidation of new functions for these enzymes, and a great progression in their structural characterization, which confirms that these two types of enzymes possess a highly conserved fold. For catalytic activity, sulfatases must contain a formylglycine residue, which is generated by various formylglycine-generating enzymes. Mechanistic and structural details have recently been obtained for a group of cofactor-independent formylglycine-generating enzymes termed FGEs. Finally, an increasing light has been cast upon the mechanism of sulfatase inactivation by a group of clinically important agents, the aryl sulfamates. [Copyright &y& Elsevier] |
| قاعدة البيانات: |
Academic Search Index |
