Effect of preoperative chemoradiotherapy on outcome of patients with locally advanced esophagogastric junction adenocarcinoma&mdash
| العنوان: | Effect of preoperative chemoradiotherapy on outcome of patients with locally advanced esophagogastric junction adenocarcinoma&mdash |
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| المؤلفون: | Orditura, M., Galizia, G., Martino, N. Di, Ancona, E., Castoro, C., Pacelli, R., Morgillo, F., Rossetti, S., Gambardella, V., Farella, A., Laterza, M.M., Ruol, A., Fabozzi, A., Napolitano, V., Iovino, F., Lieto, E., Fei, L., Conzo, G., Ciardiello, F., Vita, F. De |
| المصدر: | Current Oncology Volume 21 Issue 3 Pages 1570-133 |
| بيانات النشر: | Multidisciplinary Digital Publishing Institute, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | genetic structures, gastroesophageal junction cancer, folfox4, Preoperative chemoradiotherapy |
| الوصف: | To date, few studies of preoperative chemotherapy or chemoradiotherapy (crt) in gastroesophageal junction (gej) cancer have been statistically powered indeed, gej tumours have thus far been grouped with esophageal or gastric cancer in phase iii trials, thereby generating conflicting results. We studied 41 patients affected by locally advanced Siewert type i and ii gej adenocarcinoma who were treated with a neoadjuvant crt regimen [folfox4 (leucovorin&ndash 5-fluorouracil&ndash oxaliplatin) for 4 cycles, and concurrent computed tomography&ndash based three-dimensional conformal radiotherapy delivered using 5 daily fractions of 1.8 Gy per week for a total dose of 45 Gy], followed by surgery. Completeness of tumour resection (performed approximately 6 weeks after completion of crt), clinical and pathologic response rates, and safety and outcome of the treatment were the main endpoints of the study. All 41 patients completed preoperative treatment. Combined therapy was well tolerated, with no treatment-related deaths. Dose reduction was necessary in 8 patients (19.5%). After crt, 78% of the patients showed a partial clinical response, 17% were stable, and 5% experienced disease progression. Pathology examination of surgical specimens demonstrated a 10% complete response rate. The median and mean survival times were 26 and 36 months respectively (95% confidence interval: 14 to 37 months and 30 to 41 months respectively). On multivariate analysis, TNM staging and clinical response were demonstrated to be the only independent variables related to long-term survival. In our experience, preoperative chemoradiotherapy with folfox4 is feasible in locally advanced gej adenocarcinoma, but shows mild efficacy, as suggested by the low rate of pathologic complete response. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1718-7729 |
| DOI: | 10.3747/co.21.1570 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=multidiscipl::1664805ea7a52083d4e3eed39feaa13aTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.multidiscipl..1664805ea7a52083d4e3eed39feaa13a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17187729 |
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| DOI: | 10.3747/co.21.1570 |