دورية أكاديمية
Epithelioid Trophoblastic Tumour: A Case with Genetic Linkage to a Child Born over Seventeen Years Prior, Successfully Treated with Surgery and Pembrolizumab
| العنوان: | Epithelioid Trophoblastic Tumour: A Case with Genetic Linkage to a Child Born over Seventeen Years Prior, Successfully Treated with Surgery and Pembrolizumab |
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| المؤلفون: | David Pisani, Jean Calleja-Agius, Riccardo Di Fiore, John J. O’Leary, James P. Beirne, Sharon A. O’Toole, Ana Felix, Ian Said-Huntingford |
| المصدر: | Current Oncology, Vol 28, Iss 446, Pp 5346-5355 (2021) |
| بيانات النشر: | MDPI AG |
| سنة النشر: | 2021 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | epithelioid trophoblastic tumour, gestational trophoblastic tumour, rare gynaecological tumour, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Epithelioid trophoblastic tumours are rare neoplasms showing differentiation towards the chorion leave-type intermediate cytotrophoblast, with only a handful of cases being reported in the literature. These tumours are slow-growing and are typically confined to the uterus for extended periods of time. While the pathogenesis is unclear, they are thought to arise from a remnant intermediate trophoblast originating from prior normal pregnancies or, less frequently, gestational trophoblastic tumours. A protracted time period between the gestational event and tumour development is typical. This case describes a 49-year-old previously healthy female who presented with a completely asymptomatic uterine mass, discovered incidentally during a routine gynaecological assessment. The pathological analysis of the hysterectomy specimen confirmed an epithelioid trophoblastic tumour, involving the uterus and cervix. This is a rare gynaecological tumour. A comparative short tandem repeat analysis revealed genetic similarities to a previous healthy gestation seventeen years prior. She was successful treated with adjuvant pembrolizumab, with no evidence of disease recurrence to date. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1718-7729 1198-0052 |
| العلاقة: | https://www.mdpi.com/1718-7729/28/6/446Test; https://doaj.org/toc/1198-0052Test; https://doaj.org/toc/1718-7729Test; https://doaj.org/article/4857609d138c4b72bbbf1419a205af40Test |
| DOI: | 10.3390/curroncol28060446 |
| الإتاحة: | https://doi.org/10.3390/curroncol28060446Test https://doaj.org/article/4857609d138c4b72bbbf1419a205af40Test |
| رقم الانضمام: | edsbas.BC79D3FD |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 17187729 11980052 |
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| DOI: | 10.3390/curroncol28060446 |