Environmental toxin exposure in polycystic ovary syndrome women and possible ovarian neoplastic repercussion
| العنوان: | Environmental toxin exposure in polycystic ovary syndrome women and possible ovarian neoplastic repercussion |
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| المؤلفون: | Roberto Marci, Donatella Caserta, Tommaso Occhiali, Ilaria Soave, Chiara Assorgi |
| المصدر: | Current Medical Research and Opinion. 36:693-703 |
| بيانات النشر: | Informa UK Limited, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Glycation End Products, Advanced, Population, Socio-culturale, Endocrine Disruptors, 030204 cardiovascular system & hematology, Bioinformatics, Proinflammatory cytokine, 03 medical and health sciences, 0302 clinical medicine, Humans, Medicine, Endocrine system, Neoplastic transformation, 030212 general & internal medicine, Epigenetics, education, Ovarian Neoplasms, education.field_of_study, business.industry, advanced glycation end products, General Medicine, medicine.disease, endocrine disrupting chemicals, Polycystic ovary, advanced glycation end products, endocrine disrupting chemicals, ovarian cancer, Polycystic ovary syndrome, polycystic ovary syndrome, ovarian cancer, Cell Transformation, Neoplastic, Environmental Pollutants, Female, business, Ovarian cancer, Polycystic Ovary Syndrome, Hormone |
| الوصف: | Purpose: Over the last two decades, increasing attention has been paid to environmental toxins and their effects on the female reproductive system. Endocrine disrupting chemicals (EDCs) are exogenous substances or mixtures that can mimic the action of steroid hormones and interfere with their metabolism. Advanced glycation end products (AGEs) are proinflammatory molecules that can interact with cell surface receptors and mediate the triggering of proinflammatory pathways and oxidative stress. The purpose of this review is to explore the effects of environmental toxin exposure in the pathogenesis of both polycystic ovary syndrome (PCOS) and OC (ovarian cancer), considered separately, and also to evaluate possible neoplastic ovarian repercussion after exposure in patients diagnosed with PCOS.Materials and methods: We searched PubMed for articles published in the English language with the use of the following MeSH search terms: "polycystic ovary syndrome" and "ovarian cancer" combined with "endocrine disruptors". Titles and abstracts were examined and full articles that met the selection criteria were retrieved. A manual search of review articles and cross-references completed the search.Results: Extensive data from different studies collected in recent years concerning the effects of EDC/AGE exposure have confirmed their role in the pathophysiology of both PCOS and OC. They favor PCOS/OC development through different mechanisms that finally lead to hormonal and metabolic disruption and epigenetic modifications.Conclusions: Environmental toxin exposure in PCOS women could favor neoplastic transformation by exacerbating and potentiating some PCOS features. Further research, although difficult, is needed in order to prevent further diffusion of these substances in the environment, or at least to provide adequate information to the population considered at risk. |
| تدمد: | 1473-4877 0300-7995 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9f62e6f624f607a87b1bc329f6c10aaTest https://doi.org/10.1080/03007995.2020.1729108Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d9f62e6f624f607a87b1bc329f6c10aa |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14734877 03007995 |
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